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Ibuprofen as a template molecule for drug design against Ebola virus

dc.creatorPaessler, Slobodan
dc.creatorHuang, Cheng
dc.creatorSenćanski, Milan V.
dc.creatorVeljković, Nevena V.
dc.creatorPerović, Vladimir R.
dc.creatorGlišić, Sanja
dc.creatorVeljković, Veljko
dc.date.accessioned2018-07-02T08:58:05Z
dc.date.available2018-07-02T08:58:05Z
dc.date.issued2018
dc.identifier.issn1093-9946
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/7695
dc.description.abstractThe Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173001/RS//
dc.rightsrestrictedAccess
dc.sourceFrontiers in Bioscience - Landmark
dc.subjectdrug repositioningen
dc.subjectEbola virusen
dc.subjectentry inhibitorsen
dc.subjectglycoproteinen
dc.subjectibuprofenen
dc.titleIbuprofen as a template molecule for drug design against Ebola virusen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractВељковић, Вељко; Паесслер, Слободан; Хуанг, Цхенг; Сенћански, Милан В.; Вељковић, Невена В.; Перовић, Владимир Р.; Глишић, Сања;
dc.rights.holder© 2018 Frontiers in Bioscience
dc.citation.volume23
dc.citation.issue5
dc.citation.spage947
dc.citation.epage953
dc.citation.rankM23
dc.identifier.pmid28930583
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85047323663
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_vinar_7695


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