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dc.creatorPetrović, Danijela
dc.creatorSeke, Mariana
dc.creatorLabudović-Borović, Milica
dc.creatorJović, Danica S.
dc.creatorBorišev, Ivana
dc.creatorSrđenović, Branislava U.
dc.creatorRakočević, Zlatko Lj.
dc.creatorPavlović, Vladimir B.
dc.creatorĐorđević, Aleksandar N.
dc.date.accessioned2018-06-29T08:04:53Z
dc.date.available2018-06-29T08:04:53Z
dc.date.issued2018
dc.identifier.issn0014-4800 (print)
dc.identifier.issn1096-0945 (electronic)
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0014480017305890
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7688
dc.description.abstractIn our recent studies we have designed fullerenol/doxorubicin nanocomposite (FNP/DOX) as the new drug nanocarrier. This research has demonstrated that this novel nanocomposite has had better implications on the liver tissue in vivo (Wistar rats treated intraperitoneally), than treatment based only on DOX. FNP/DOX has been characterised by DLS, TEM and AFM measurements which have shown that DOX loaded onto FNP did not influence fullerenol nanoparticle's size. FNP/DOX affected oxidative status in blood causing a significant decrease of catalase and SOD activity in comparison to DOX, implicating the reduction in oxidative stress. qRT-PCR results on the mRNA level of antioxidative enzymes (catalase and MnSOD) revealed that the effect of oxidative stress is significantly reduced by the treatment with FNP/DOX (p <.05). The ultrastructural analysis of the liver tissue has revealed that FNP/DOX nanocomposite generated considerably less damage in the liver tissue, than DOX applied at the same dose. Hence, our results have indicated that FNP, within FNP/DOX nanocomposite, exhibits protective effects to the liver tissue of the healthy rats.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45005/RS//
dc.rightsrestrictedAccess
dc.sourceExperimental and Molecular Pathology
dc.subjectfullerenol/doxorubicin nanocompositeen
dc.subjectdrug deliveryen
dc.subjectAFMen
dc.subjectqRT-PCRen
dc.subjectultrastructural analysisen
dc.titleHepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy ratsen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractСеке, Мариана; Јовић, Даница С.; Боришев, Ивана; Срђеновић, Бранислава У.; Ђорђевић, Aлександар Н.; Лабудовић-Боровић, Милица; Петровић, Данијела; Ракочевић, Златко Љ.; Павловић, Владимир Б.;
dc.rights.holder© 2018 Published by Elsevier Inc.
dc.citation.volume104
dc.citation.issue3
dc.citation.spage199
dc.citation.epage211
dc.identifier.wos000434907600005
dc.identifier.doi10.1016/j.yexmp.2018.04.005
dc.identifier.pmid29727604
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85046811167


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