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Značaj promena broja kopija FGFR1 i c-MYC gena u trostruko negativnim karcinomima dojke

dc.creatorNedeljković, Milica
dc.creatorTanić, Nikola
dc.creatorDramićanin, Tatjana
dc.creatorMilovanović, Zorka M.
dc.creatorŠušnjar, Snežana
dc.creatorMilinković, Vedrana
dc.creatorVujović, Ivana
dc.creatorTanić, Nasta
dc.date.accessioned2018-06-28T07:44:05Z
dc.date.available2018-06-28T07:44:05Z
dc.date.issued2018
dc.identifier.issn1452-8258 (print)
dc.identifier.urihttp://content.sciendo.com/view/journals/jomb/ahead-of-print/article-10.1515-jomb-2018-0012.xml
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7683
dc.description.abstract© 2018 Milica Nedeljković et al., published by De Gruyter Open 2018. Background: Triple negative breast cancer (TNBC) is characterized by aggressive clinical course and is unresponsive to anti-HER2 and endocrine therapy. TNBC is difficult to treat and is often lethal. Given the need to find new targets for therapy we explored clinicopathological significance of copy number gain of FGFR1 and c-MYC. Our aim was to determine the impact of FGFR1 and c-MYC copy number gain on clinical course and outcome of TNBC. Methods: FGFR1 and c-MYC gene copy number alterations were evaluated in 78 archive TNBC samples using TaqMan based quantitative real time PCR assays. Results: 50% of samples had increased c-MYC copy number. c-MYC copy number gain was associated with TNBC in contrast to ER positive cancers. Our results showed significant correlation between c-MYC copy number gain and high grade of TNBCs. This suggests that c-MYC copy number could be an useful prognostic marker for TNBC patients. c-MYC copy number gain was associated with high pTNM stage as well as lobular and medullary tumor subtypes. 43% of samples had increased FGFR1 copy number. No correlations between FGFR1 copy number gain and clinicopathological variables were observed. Conclusions: We identified c-MYC copy number gain as a prognostic marker for TNBC. Our results indicate that c- MYC may contribute to TNBC progression. We observed no significant association between c-MYC and/or FGFR1 copy number status and patient survival.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.subjectc-MYCen
dc.subjectcopy number gainen
dc.subjectFGFR1en
dc.subjecttriple negative breast canceren
dc.titleImportance of Copy Number Alterations of FGFR1 and C-MYC Genes in Triple Negative Breast Canceren
dc.titleZnačaj promena broja kopija FGFR1 i c-MYC gena u trostruko negativnim karcinomima dojkesr
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractВујовић, Ивана; Танић, Наста; Танић, Никола; Драмићанин, Татјана; Миловановић, Зорка М.; Шушњар, Снежана; Милинковић, Ведрана; Недељковић, Милица;
dc.citation.volume37
dc.citation.issue2
dc.citation.spage1
dc.citation.epage8
dc.identifier.doi10.1515/jomb-2018-0012
dc.identifier.scopus2-s2.0-85046649499
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/10073/Nedeljkovic_2018_Importance_of_Copy_Number_Alterations.pdf


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