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dc.creatorŽivković, Maja
dc.creatorKolić, Ivana
dc.creatorJešić, Snežana
dc.creatorJotić, Ana
dc.creatorStanković, Aleksandra
dc.date.accessioned2018-06-26T06:49:32Z
dc.date.available2018-06-26T06:49:32Z
dc.date.issued2018
dc.identifier.issn1976-8710 (print)
dc.identifier.issn2005-0720 (electronic)
dc.identifier.urihttp://e-ceo.org/journal/view.php?doi=10.21053/ceo.2017.01060
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7677
dc.description.abstractObjectives. Chronic otitis media (COM) is followed by irreversible tissue damage and destruction of the middle ear structures, with the possibility of complications under the maintenance of inflammation. Inflammatory mediators such as cytokines play a crucial role in the initial stage of inflammation. The aim of this study was to evaluate the association of the polymorphisms in two innate immunity/inflammation cascade genes from interleukin-1 (IL-1) gene cluster with COM with regard to cholesteatoma. Methods. In the cross-sectional case-control study, DNA samples were collected from 189 patients with COM and 119 controls from a population of Serbia. The +3953 C/T (rs1143634), TaqI polymorphism in interleukin-1 beta (IL-1Β) gene and 86 bp variable number tandem repeat (VNTR, rs2234663) polymorphism in the IL-1 receptor antagonist (IL-1RA) gene were analyzed by polymerase chain reaction. Results. The IL-1Β TaqI polymorphism was not significantly different in patients compared with the control group. The significant difference between patients and controls was observed for both, genotype and allele frequencies of IL-1RA VNTR polymorphism (chi-square P<0.01). We found that carriers of IL-1RA allele 2 (odds ratio, 0.47; 95% confidence interval, 0.29 to 0.76; P=0.004) have a favorable association with COM, using multivariate logistic analysis that included both polymorphisms, age and sex. The IL-1RA allele frequency distribution was significantly different with regard to cholesteatoma. Conclusion. The carriers of allele 2 of VNTR IL-1RA polymorphism had a decreased odds ratio for COM, which is in agreement with findings in other inflammatory disease and its previous association with higher IL-1RA levels. Possible down-regulation of IL-1 mediated proinflammatory signaling pathways via IL-1RA in COM as well as results of our study should be further investigated and replicated.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS//
dc.rightsopenAccess
dc.sourceClinical and Experimental Otorhinolaryngology
dc.subjectcholesteatomaen
dc.subjectgenetic polymorphismen
dc.subjectinterleukin-1 receptor antagonisten
dc.subjectinterleukin-1Betaen
dc.subjectotitis mediaen
dc.titleThe Allele 2 of the VNTR Polymorphism in the Gene That Encodes a Natural Inhibitor of IL-1β, IL-1RA Is Favorably Associated With Chronic Otitis Mediaen
dc.typearticleen
dc.rights.licenseBY-NC
dcterms.abstractЈотић, Aна; Станковић, Aлександра; Живковић, Маја; Колић, Ивана; Јешић, Снежана;
dc.rights.holder© 2018 by Korean Society of Otorhinolaryngology-Head and Neck Surgery
dc.citation.volume11
dc.citation.issue2
dc.citation.spage118
dc.citation.epage123
dc.identifier.wos000433270700007
dc.identifier.doi10.21053/ceo.2017.01060
dc.identifier.pmid29433161
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85046099306
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/10063/Zivkovic_2017_The_allele_2_of_the_VNTR.pdf


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