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dc.creatorVasić, Novak
dc.creatorGlumac, Sofija
dc.creatorPejić, Snežana
dc.creatorAmidžić, L. J.
dc.creatorTadić-Latinović, Ljiljana J.
dc.creatorDožić, Branko S.
dc.creatorHinić, Saša
dc.creatorMaksimović, Živan
dc.date.accessioned2018-06-26T06:49:10Z
dc.date.available2018-06-26T06:49:10Z
dc.date.issued2017
dc.identifier.issn0015-5500
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/7676
dc.description.abstract© 2017 Charles University. All rights reserved. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a complex role in the pathogenesis of atherosclerosis. We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development. Samples were obtained from 30 patients with AAA and 30 with AOD. Aortic histology and immunohistochemistry were performed to evaluate inflammatory changes and MMP and TIMP expression. Thrombosis and ulceration were more frequent in AOD than in AAA. The MMP-9 expression was elevated in all aortic layers of AAA patients and in media/adventitia of AOD patients, mainly followed by lower expression of its inhibitor TIMP-1. Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. These results showed that both conditions exhibited increased MMP-9 expression; however, the MMP expression pattern differed to some degree between the aneurysms and occlusive disease. The variations in molecular mechanisms underlying dilatative/stenosing disease warrant further investigation.
dc.relationMinistry of Science and Technology of the Republic of Srpska
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceFolia Biologica (Czech Republic)
dc.subjectabdominal aortic aneurysmen
dc.subjectaortoiliac occlusive diseaseen
dc.subjectmatrix metalloproteinasesen
dc.subjectsyndrome Lericheen
dc.titleExpression of matrix metalloproteinases and endogenous inhibitors in abdominal aortic aneurysm and aortoiliac occlusive disease (syndrome leriche)en
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractМаксимовић, Живан; Глумац, Софија; Васић, Н.; Пејић, Снежана; Aмиджић, Л. Ј.; Тадић Латиновић, Л. Ј.; Дожић, Бранко С.; Хинић, Саша;
dc.rights.holder© 2017 Charles University
dc.citation.volume63
dc.citation.issue5-6
dc.citation.spage209
dc.citation.epage216
dc.citation.rankM23
dc.identifier.pmid29687775
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85046155361
dc.identifier.fulltexthttps://vinar.vin.bg.ac.rs//bitstream/id/10062/Vasic_2017_Expression_of_matrix_metalloproteinases.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_vinar_7676


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