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dc.contributor.authorFilipović, Dragana
dc.contributor.authorStanisavljević, Andrijana
dc.contributor.authorJasnić, Nebojša
dc.contributor.authorBernardi, Rick E.
dc.contributor.authorInta, Dragos
dc.contributor.authorPerić, Ivana
dc.contributor.authorGass, Peter
dc.date.accessioned2018-03-10T17:37:55Z
dc.date.available2018-03-10T17:37:55Z
dc.date.issued2018
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7584
dc.description.abstractThe dysfunction of parvalbumin-positive (PV+) interneurons, the most abundant type of hippocampal GABAergic inhibitory interneuron, has been implicated in mood disorders. We recently reported that adult male Wistar rats exposed to three weeks of social isolation show depressive-and anxiety-like behaviors and a reduced number of PV+ interneurons in all hippocampal subregions. As GABA neurotransmission has been proposed as a potential therapeutic target of antidepressant and antipsychotic medications, we examined whether treatment with the antidepressant fluoxetine (Flx) (15 mg/kg/day) or the antipsychotic clozapine (Clz) (20 mg/kg/day) during three weeks of social isolation in rats offered protection from the isolation stress-induced reduction in the number of PV+ interneurons in hippocampal subregions. Using immunofluorescence analysis, we revealed that both chronic Flx and Clz partially prevented the isolation-induced changes. Flx prevented the reduction in the number of PV+ interneurons in the CA2, CA3, without affecting the CA1 and dentate gyrus DG areas, whereas Clz prevented this decrement in the CA2, CA3 and DG regions but not in CA1 areas. Moreover, Flx increased the number of PV+ interneurons in CA1 in control animals. These findings suggest that chronic administration of Flx or Clz may offer partial protection from social isolation stress via modulation of the hippocampal GABAergic system. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173023/RS//
dc.relationDeutsche Forschungsgemeinschaft [IN168/3-1, SFB636-TP3]; Ingeborg Stander Foundation; Research Fund of the UPK Basel; German Ministry of Education and Research (BMBF) [01GQ1003B]
dc.rightsrestrictedAccessen
dc.sourceNeuroscienceen
dc.subjectchronic social isolationen
dc.subjectfluoxetineen
dc.subjectclozapineen
dc.subjectparvalbuminen
dc.subjecthippocampusen
dc.titleChronic Treatment with Fluoxetine or Clozapine of Socially Isolated Rats Prevents Subsector-Specific Reduction of Parvalbumin Immunoreactive Cells in the Hippocampusen
dc.typearticleen
dc.citation.volume371
dc.citation.spage384
dc.citation.epage394
dc.identifier.wos000425876200031
dc.identifier.doi10.1016/j.neuroscience.2017.12.020
dc.identifier.pmid29275206
dc.identifier.scopus2-s2.0-85040029943


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