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Multifunctional hydroxyapatite and poly(D,L-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol

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2013
7565.pdf (1.893Mb)
Authors
Ignjatović, Nenad L.
Uskoković, Vuk
Ajduković, Zorica
Uskoković, Dragan
Article (Accepted Version)
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Abstract
Cholecalciferol, vitamin D3, plays an important role in bone metabolism by regulating extracellular levels of calcium. Presented here is a study on the effects of the local delivery of cholecalciferol (D3) using nanoparticulate carriers composed of hydroxyapatite (HAp) and poly(D,L-lactide-co-glycolide) (PLGA). Multifunctional nanoparticulate HAp-based powders were prepared for the purpose of: (a) either fast or sustained, local delivery of cholecalciferol, and (b) the secondary, osteoconductive and defect-filling effect of the carrier itself. Two types of HAp-based powders with particles of narrowly dispersed sizes in the nano range were prepared and tested in this study: HAp nanoparticles as direct cholecalciferol delivery agents and HAp nanoparticles coated with cholecalciferol-loaded poly(D,L)-lactide-co-glycolide (HAp/D3/PLGA).Satisfying biocompatibility of particulate systems, when incubated in contact with MC3T3-E1 osteoblastic cells in vitro, was observed for HAp/D3/PLGA and pu...re HAp. In contrast, an extensively fast release of cholecalciferol from the system comprising HAp nanoparticles coated with cholecalciferol (HAp/D3) triggered necrosis of the osteoblastic cells in vitro. Artificial defects induced in the osteoporotic bone of the rat mandible were successfully reconstructed following implantation of cholecalciferol-coated HAp nanoparticles as well as those comprising HAp nanoparticles coated with cholecalciferol-loaded PLGA (HAp/D3/PLGA). The greatest levels of enhanced angiogenesis, vascularization, osteogenesis and bone structure differentiation were achieved upon the implementation of HAp/D3/PLGA systems.

Keywords:
Multifunctional nano materials / Cholecalciferol / HAp / PLGA / Osteogenesis
Source:
Materials Science and Engineering: C, 2013, 33, 2, 943-950
Projects:
  • US National Health Institute grant K99-DE021416
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
Note:
  • This is the peer-reviewed version of the articleIgnjatović, N., Uskoković, V., Ajduković, Z., Uskoković, D., 2013. Multifunctional hydroxyapatite and poly(d,l-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol. Materials Science and Engineering: C 33, 943–950. https://doi.org/10.1016/j.msec.2012.11.026

DOI: 10.1016/j.msec.2012.11.026

ISSN: 0928-4931

[ Google Scholar ]
URI
http://itn.sanu.ac.rs/opus4/frontdoor/index/index/docId/1250
http://itn.sanu.ac.rs/opus4/files/1250/10.1016-j.msec.2012.11.026.pdf
http://dais.sanu.ac.rs/123456789/15982
http://vinar.vin.bg.ac.rs/handle/123456789/7571
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