Antioxidant status in women with uterine leiomyoma: relation with sex hormones
2015
Аутори
Pejić, SnežanaTodorović, Ana
Stojiljković, Vesna
Gavrilović, Ljubica
Popović, Nataša M.
Pajović, Snežana B.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Uterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients with leiomyoma are influenced by changes in sex hormones and gonadotropins (estradiol (E2), progesterone, FSH, and LH) during menstrual cycle and in postmenopause. The material consisted of blood and uterine tissue specimens. Hormone concentrations were determined and assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and lipid hydroperoxides concentration were performed. In blood of examined women, a significant difference in catalase, glutathione peroxidase and glutathione reductase activity was recorded among the phases. There was also a positive correlation between the estradiol/progesterone concentration and the catalase activity. Progesterone negatively correlated with lipid hydrop...eroxides level. In myoma tissue, we recorded a phase-related difference in lipid hydroperoxides level and activities of superoxide dismutase, glutathione peroxidase activities, and glutathione reductase. Negative correlation was observed between FSH and glutathione peroxidase. The results suggest that antioxidant status in patients with uterine leiomyoma is influenced by the changes in sex hormones during the menstrual cycle and in postmenopause, indicating a role of the observed relationship in the leiomyoma etiology.
Кључне речи:
antioxidant enzymes / lipid hydroperoxides / sex steroids / leiomyomaИзвор:
Anais de Academia Brasileira de Ciencias, 2015, 87, 3, 1771-1782Финансирање / пројекти:
- Ћелијске и молекулске основе малигних и кардиоваскуларних обољења-клиничке импликације (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Акутни коронарни синдром: истраживање вулнерабилности (плака, крви и миокарда), оптимално лечење и одређивање прогностичких фактора (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41022)
DOI: 10.1590/0001-3765201520130416
ISSN: 0001-3765; 1678-2690
PubMed: 26421458
WoS: 000361842000023
Scopus: 2-s2.0-84942354111
Колекције
Институција/група
VinčaTY - JOUR AU - Pejić, Snežana AU - Todorović, Ana AU - Stojiljković, Vesna AU - Gavrilović, Ljubica AU - Popović, Nataša M. AU - Pajović, Snežana B. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/751 AB - Uterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients with leiomyoma are influenced by changes in sex hormones and gonadotropins (estradiol (E2), progesterone, FSH, and LH) during menstrual cycle and in postmenopause. The material consisted of blood and uterine tissue specimens. Hormone concentrations were determined and assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and lipid hydroperoxides concentration were performed. In blood of examined women, a significant difference in catalase, glutathione peroxidase and glutathione reductase activity was recorded among the phases. There was also a positive correlation between the estradiol/progesterone concentration and the catalase activity. Progesterone negatively correlated with lipid hydroperoxides level. In myoma tissue, we recorded a phase-related difference in lipid hydroperoxides level and activities of superoxide dismutase, glutathione peroxidase activities, and glutathione reductase. Negative correlation was observed between FSH and glutathione peroxidase. The results suggest that antioxidant status in patients with uterine leiomyoma is influenced by the changes in sex hormones during the menstrual cycle and in postmenopause, indicating a role of the observed relationship in the leiomyoma etiology. T2 - Anais de Academia Brasileira de Ciencias T1 - Antioxidant status in women with uterine leiomyoma: relation with sex hormones VL - 87 IS - 3 SP - 1771 EP - 1782 DO - 10.1590/0001-3765201520130416 ER -
@article{ author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.", year = "2015", abstract = "Uterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients with leiomyoma are influenced by changes in sex hormones and gonadotropins (estradiol (E2), progesterone, FSH, and LH) during menstrual cycle and in postmenopause. The material consisted of blood and uterine tissue specimens. Hormone concentrations were determined and assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and lipid hydroperoxides concentration were performed. In blood of examined women, a significant difference in catalase, glutathione peroxidase and glutathione reductase activity was recorded among the phases. There was also a positive correlation between the estradiol/progesterone concentration and the catalase activity. Progesterone negatively correlated with lipid hydroperoxides level. In myoma tissue, we recorded a phase-related difference in lipid hydroperoxides level and activities of superoxide dismutase, glutathione peroxidase activities, and glutathione reductase. Negative correlation was observed between FSH and glutathione peroxidase. The results suggest that antioxidant status in patients with uterine leiomyoma is influenced by the changes in sex hormones during the menstrual cycle and in postmenopause, indicating a role of the observed relationship in the leiomyoma etiology.", journal = "Anais de Academia Brasileira de Ciencias", title = "Antioxidant status in women with uterine leiomyoma: relation with sex hormones", volume = "87", number = "3", pages = "1771-1782", doi = "10.1590/0001-3765201520130416" }
Pejić, S., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M.,& Pajović, S. B.. (2015). Antioxidant status in women with uterine leiomyoma: relation with sex hormones. in Anais de Academia Brasileira de Ciencias, 87(3), 1771-1782. https://doi.org/10.1590/0001-3765201520130416
Pejić S, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pajović SB. Antioxidant status in women with uterine leiomyoma: relation with sex hormones. in Anais de Academia Brasileira de Ciencias. 2015;87(3):1771-1782. doi:10.1590/0001-3765201520130416 .
Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Pajović, Snežana B., "Antioxidant status in women with uterine leiomyoma: relation with sex hormones" in Anais de Academia Brasileira de Ciencias, 87, no. 3 (2015):1771-1782, https://doi.org/10.1590/0001-3765201520130416 . .