Applicability of neural networks in the estimation of brain iron content in the diagnosis of amyotrophic lateral sclerosis
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Artificial Neural Networks, or simply ANN, are mathematical/computational model that are inspired by structure and functional aspects of biological neural networks. ANN, like man, learns by example. In the process of network training, network is supplied with set of data which represents examples of network’s proper behaviour. In the research we have done, neural network is created with the task to estimate the iron content in the brain of the Amyotrophic Lateral Sclerosis (ALS) patients. Network is created and trained using Neural Pattern Recognition Tool within the software package Matlab v220.127.116.119 (R2010a). Network is trained with set of data obtained from group of 50 ALS patients. Training set contains: (i) MRI signal of brain iron, (ii) EPR signal of hydroxyl radical from cerebrospinal fluid and (iii) score on ALS Functional Rating Scale (ALSFRS) for each patient individually. The results indicate that neural networks can be successfully used to predict the high content of iron ...in the brain, which in the perspective opens up the possibility of using this computer model as a standard tool in the diagnosis of ALS.
Keywords:artificial neural networks / iron content / brain / amyotrophic lateral sclerosis / diagnosis
Source:Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia, 2011, 10-10
- Belgrade : Institute of Technical Sciences of SASA