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Examination of the influence of nanomaterials calcium phosphate/poly(DL-lactide-co-glycolide) and cobalt-exchanged hydroxyapatite on the viability of Saos-2 cells

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2012
7460.pdf (174.6Kb)
Authors
Najman, Stevo
Stojanović, Sanja
Mitrić, Žarko
Ajduković, Zorica
Ignjatović, Nenad L.
Uskoković, Dragan
Contributors
Grbović-Novaković, Jasmina
Ignjatović, Nenad L.
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Abstract
We have examined the effect of extracts of the calcium phosphate/poly(DL-lactide-co-glycolide) (CP/PLGA) and cobalt-exchanged hydroxyapatite (CoHAp), on the viability of Saos2 osteoblastlike cells. Extracts were prepared by incubation for 3 days at 37°C in the cultivation medium. Conductivity and pH value of extracts were measured before viability assay. Cell viability was estimated by MTT test performed after 24 h incubation of cells with various concentrations of extracts. Extract of CP/PLGA acted more cytotoxic on osteoblasts than the extract of CoHAp. This difference in the effect of examined extracts can be explained by their different pH value and conductivity.
Keywords:
calcium phosphate / poly(DL-lactide-co-glycolide) / Saos2 cells / cobalt-exchanged hydroxyapatite / biomaterials
Source:
Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts, 2012, 110-110
Publisher:
  • Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade
Projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)

ISBN: 9788673061221

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URI
http://dais.sanu.ac.rs/123456789/519
http://www.itn.sanu.ac.rs/opus4/frontdoor/index/index/docId/786
http://www.itn.sanu.ac.rs/opus4/files/786/Najman_11KMI.pdf
http://vinar.vin.bg.ac.rs/handle/123456789/7466
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