Show simple item record

dc.creatorVučen, Sonja
dc.creatorVuleta, Gordana
dc.creatorCrean, Abina
dc.creatorMoore, Anne C.
dc.creatorIgnjatović, Nenad L.
dc.creatorUskoković, Dragan
dc.date.accessioned2018-03-06T09:05:47Z
dc.date.available2018-03-06T09:05:47Z
dc.date.issued2013
dc.identifier.issn0022-3573 (Print) 2042-7158 (Online)
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/383
dc.identifier.urihttp://www.itn.sanu.ac.rs/opus4/frontdoor/index/index/docId/644
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7412
dc.description.abstractAbstractObjectivesThe aim of our study was to evaluate the effect of designing ketoprofen-loaded nanosized spheres and combining them with solid silicon microneedles for enhanced and sustained percutaneous drug delivery.MethodsKetoprofen-loaded nanoparticles (KET-NP) were designed by modified solvent displacement method, using poly (D, L-lactic acid) (PDLLA). All prepared nanoparticles were characterised with regard to their particle size distribution, morphology, surface properties, thermal behaviour, drug content, drug release and stability. In-vitro skin permeation studies were conducted on Franz-type diffusion cells using porcine skin treated with ImmuPatch silicon microneedles (Tyndall Nation Institute, Cork, Ireland).Key findingsThe study showed that uniform nanospheres were prepared with high encapsulation efficiency and retained stable for 2 months. After an initial burst release, the PDLLA nanoparticles were capable of sustaining and controlling ketoprofen release that followed Korsmeyer–Peppas kinetics. An enhanced flux of ketoprofen was observed in the skin treated with silicon microneedles over a prolonged period of time.ConclusionsFollowing application of silicon microneedle arrays, KET-NP were able to enhance ketoprofen flux and supply the porcine skin with drug over a prolonged (24 h) period of time. Our findings indicate that the delivery strategy described here could be used for the further development of effective and painless administration systems for sustained percutaneous delivery of ketoprofen.en
dc.format65 10 (2013) 1451-1462
dc.languageen
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmacy and Pharmacologyen
dc.subjectketoprofen
dc.subjectmicroneedles
dc.subjectnanoparticles
dc.subjectskin
dc.titleImproved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedlesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВулета, Гордана; Вучен, Соња; Цреан, Aбина; Мооре, Aнне Ц.; Игњатовић, Ненад; Ускоковић, Драган;
dc.citation.spage1451
dc.citation.epage1462
dc.identifier.doi10.1111/jphp.12118


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record