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Multifunctional hydroxyapatite and poly(D,L-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol
dc.creator | Ignjatović, Nenad L. | |
dc.creator | Uskoković, Vuk | |
dc.creator | Ajduković, Zorica | |
dc.creator | Uskoković, Dragan | |
dc.date.accessioned | 2018-03-06T09:05:38Z | |
dc.date.available | 2018-03-06T09:05:38Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0928-4931 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/7411 | |
dc.description.abstract | Cholecalciferol, vitamin D3, plays an important role in bone metabolism by regulating extracellular levels of calcium. Presented here is a study on the effects of the local delivery of cholecalciferol (D3) using nanoparticulate carriers composed of hydroxyapatite (HAp) and poly(d,l-lactide-co-glycolide) (PLGA). Multifunctional nanoparticulate HAp-based powders were prepared for the purpose of: (a) either fast or sustained, local delivery of cholecalciferol, and (b) the secondary, osteoconductive and defect-filling effect of the carrier itself. Two types of HAp-based powders with particles of narrowly dispersed sizes in the nano range were prepared and tested in this study: HAp nanoparticles as direct cholecalciferol delivery agents and HAp nanoparticles coated with cholecalciferol-loaded poly(d,l)-lactide-co-glycolide (HAp/D3/PLGA).Satisfying biocompatibility of particulate systems, when incubated in contact with MC3T3-E1 osteoblastic cells in vitro, was observed for HAp/D3/PLGA and pure HAp. In contrast, an extensively fast release of cholecalciferol from the system comprising HAp nanoparticles coated with cholecalciferol (HAp/D3) triggered necrosis of the osteoblastic cells in vitro. Artificial defects induced in the osteoporotic bone of the rat mandible were successfully reconstructed following implantation of cholecalciferol-coated HAp nanoparticles as well as those comprising HAp nanoparticles coated with cholecalciferol-loaded PLGA (HAp/D3/PLGA). The greatest levels of enhanced angiogenesis, vascularization, osteogenesis and bone structure differentiation were achieved upon the implementation of HAp/D3/PLGA systems. | en |
dc.format | 33 2 (2013) 943-950 | |
dc.language | en | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS// | |
dc.rights | restrictedAccess | |
dc.source | Materials Science and Engineering: C | en |
dc.subject | multifunctional nanomaterials | |
dc.subject | cholecalciferol | |
dc.subject | hydroxyapatite | |
dc.subject | poly(d,l-lactide-co-glycolide) | |
dc.subject | vitamin D3 | |
dc.title | Multifunctional hydroxyapatite and poly(D,L-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferol | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ускоковић, Вук; Ускоковић, Драган; Игњатовић, Ненад; Aјдуковић, Зорица; | |
dc.citation.spage | 943 | |
dc.citation.epage | 950 | |
dc.identifier.wos | 000315761700053 | |
dc.identifier.doi | 10.1016/j.msec.2012.11.026 | |
dc.citation.rank | M22 | |
dc.description.other | Peer-reviewed version of the article (Accepted Manuscript or postprint) available at: [https://vinar.vin.bg.ac.rs/handle/123456789/7571] | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-84871364442 |
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