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dc.creatorŠvorc, Lubomir
dc.creatorBorovska, Katarina
dc.creatorCinkova, Kristina
dc.creatorStanković, Dalibor M.
dc.creatorPlankova, Alexandra
dc.date.accessioned2018-03-03T15:07:48Z
dc.date.available2018-03-03T15:07:48Z
dc.date.issued2017
dc.identifier.issn0013-4686 (print)
dc.identifier.issn1873-3859 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7183
dc.description.abstractAn innovative, rapid and simple electrochemical approach for the reliable quantification of cytostatic drug flutamide (FLU) in various matrices is herein proposed. This platform involves coupling of differential pulse (DPV) and square-wave voltammetry (SWV) with a boron-doped diamond (BDD) electrode as the working electrode and 0.1 M sulphuric acid as the supporting electrolyte. For the first time, the voltammetric profile of FLU was manifested by three irreversible and diffusion-controlled oxidation peaks at + 1.1 (P1), + 1.4 (P2) and + 1.9 V (P3). The analytical performance evaluation was assessed for all three peaks, using both pulse voltammetric techniques with the optimized operating parameters and the highest sensitivity of 1.76 nA/mu M was accomplished for P2 using DPV and 3.54 nA/mu M for P3 using SWV. The corresponding linear concentration ranges were found to be 0.99-42.9 and 4.8-35.5 mu M with the detection limits of 0.42 and 0.18 mu M, respectively. The repeatability varied, depending on the oxidation peaks of FLU, with the relative standard deviations in the range of 3.3-8.8% and 2.9-9.3% for DPV and SWV, respectively. The proposed electrochemical platform was successfully applied in the analysis of pharmaceutical formulations, spiked human urine and water samples with the significant mean recoveries. Using BDD electrode, the current work establishes an advanced, simple and rapid alternative platform to so far used toxic mercury-based electrodes and time demanding chemically modified electrodes in cytostatic sensing. Besides, BDD electrode represents a comfortable electrochemical sensor for routine analysis in pharmaceutical, clinical and environmental chemistry. (C) 2017 Elsevier Ltd. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS//
dc.relationGrant Agency of the Slovak Republic [1/0489/16], MagBioVin project, Grant scheme for Support of Young Researchers and Excellent Teams of Young Researchers
dc.rightsrestrictedAccessen
dc.sourceElectrochimica Actaen
dc.subjectcytostatic drug flutamideen
dc.subjectboron-doped diamond electrodeen
dc.subjectelectrochemical sensoren
dc.subjectdifferential pulse voltammetryen
dc.subjectsquare-wave voltammetryen
dc.titleAdvanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrodeen
dc.typearticleen
dcterms.abstractБоровска, Катарина; Планкова, Aлеxандра; Цинкова, Кристина; Сворц, Лубомир; Станковић Далибор;
dc.citation.volume251
dc.citation.spage621
dc.citation.epage630
dc.identifier.wos000413004200067
dc.identifier.doi10.1016/j.electacta.2017.08.077
dc.description.other11th International Symposium on Electrochemical Micro and Nanosystem Technologies (EMNT), Aug 17-19, 2016, Royal Belgian Inst Nat Sci, Brussels, Belgiumen
dc.identifier.scopus2-s2.0-85028691293


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