Show simple item record

dc.creatorBajić, Vladan P.
dc.creatorSpremo-Potparević, Biljana
dc.creatorŽivković, Lada
dc.creatorIsenović, Esma R.
dc.creatorArendt, Thomas
dc.date.accessioned2018-03-01T16:18:19Z
dc.date.available2018-03-01T16:18:19Z
dc.date.issued2015
dc.identifier.issn0149-7634 (print)
dc.identifier.issn1873-7528 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/664
dc.description.abstractNeurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimers disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to core cell cycle regulators are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsrestrictedAccessen
dc.sourceNeuroscience and Biobehavioral Reviewsen
dc.subjectAlzheimers disease (AD)en
dc.subjectAneuploidyen
dc.subjectGenomic mosaicismen
dc.subjectCell cycleen
dc.subjectCohesionen
dc.titleCohesion and the aneuploid phenotype in Alzheimers disease: A tale of genome instabilityen
dc.typereviewen
dcterms.abstractИсеновић Есма; Aрендт, Тхомас; Зивковиц, Лада; Спремо-Потпаревиц, Биљана; Бајић Владан П.;
dc.citation.volume55
dc.citation.spage365
dc.citation.epage374
dc.identifier.wos000358271000025
dc.identifier.doi10.1016/j.neubiorev.2015.05.010
dc.citation.rankM21a
dc.identifier.pmid26003528
dc.identifier.scopus2-s2.0-84930622205


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record