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dc.creatorFilipović, Dragana
dc.creatorGavrilović, Ljubica
dc.creatorDronjak, Slađana
dc.creatorRadoičić, Marija B.
dc.date.accessioned2018-03-03T14:22:23Z
dc.date.available2018-03-03T14:22:23Z
dc.date.issued2007
dc.identifier.issn0077-8923 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/6649
dc.description.abstractSensitivity of target cells to glucocorticoids is regulated by the expression of intracellular glucocorticoid receptor (GR), which mediates the effects of glucocorticoids. The level of GR and of its nuclear transporter protein 70 (Hsp70) were followed in hippocampus and brain cortex of adult Wistar rat males exposed to acute (immobilization, cold) and chronic (social isolation, isolation, and 15 min daily swimming) stress or their combinations. Changes in plasma levels of adenocorticotropic hormone and corticosterone were also studied. A significant decrease in cytosol GR and Hsp70 was observed after acute stress. Opposite to that, chronic stress led to negligible changes in both cytosol GR and Hsp70 levels. Isolation, as chronic psychosocial stressor, caused reduced responsiveness to novel acute stressors, judged by the cytosol GR and Hsp70 levels. This was not observed if chronic isolation was combined with 15 min daily swimming prior to acute exposure to immobilization. The data suggest that repeated physical exercise may, at least in some cases, diminish detrimental effects of chronic social isolation on limbic-hypothalamic-pituitary-adrenocortical axis, as judged by the levels of GR and Hsp70 in the Wistar rat brain.en
dc.rightsrestrictedAccessen
dc.sourceAnnals of the New York Academy of Sciencesen
dc.subjectneuroendocrine stressen
dc.subjectglucocorticoid receptoren
dc.subjectheat shock protein 70en
dc.subjectrat brainen
dc.titleThe effect of repeated physical exercise on hippocampus and brain cortex in stressed ratsen
dc.typearticleen
dcterms.abstractДроњак Слађана; Радоичић Марија; Филиповић Драгана; Гавриловић Љубица;
dc.citation.volume1096
dc.citation.spage207
dc.citation.epage219
dc.identifier.wos000245947600023
dc.identifier.doi10.1196/annals.1397.087
dc.citation.rankM21
dc.identifier.pmid17405932
dc.description.otherCell Signaling World 2006 Conference, Jan 25-28, 2006, Luxembourg, Luxembourgen
dc.identifier.scopus2-s2.0-34247248330


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