Effects of metal ions on plasma membrane Mg2+-ATPase in rat uterus and ovaries
Чланак у часопису
МетаподациПриказ свих података о документу
The in vitro effects of cadmium and mercury were investigated on the Mg2+-ATPase activity of plasma membranes from the rat ovary and uterus. ATP hydrolyzing activities were significant and dose-dependent-inhibited in both plasma membrane preparations by both metals. According to the IC50 and apparent K-i, Cd2+ was most potent in the ovary, while Hg2+ was most potent in the uterus. In ovaries and uterus,Cd2+ inhibits competitively, while Hg2+ inhibits noncompetitively in both organs. The observed inhibition was a consequence of direct action of the chosen metal ions on the enzyme protein and by decreasing ATP hydrolysis, Hg2+ and Cd2+ may affect mammalian fertility.
Кључне речи:Mg2+-ATPase / ecto-ATPase / cadmium / mercury / ovary / uterus / rat
Извор:Annals of the New York Academy of Sciences, 2005, 1048, 445-448
- 22nd International Biophysics Symposium, Oct 09-14, 2004, Belgrade, Serbia
ISSN: 0077-8923 (print)