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A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics
dc.creator | Savić, Danka A. | |
dc.creator | Jelić, Smiljana | |
dc.date.accessioned | 2018-03-03T14:14:21Z | |
dc.date.available | 2018-03-03T14:14:21Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0077-8923 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/6555 | |
dc.description.abstract | Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another plausible explanation of the origin of this pattern: HPA just responds to an external pacemaker. A qualitative mathematical model is constructed wherein all the terms in the equations are physicochemically interpretable. Linear stability analysis shows that this system does not generate oscillations. Computer simulation yields oscillations that are the systems response to an external pulsing activator, implying that the observed pattern does not have to be an intrinsic property of this system. | en |
dc.rights | restrictedAccess | en |
dc.source | Annals of the New York Academy of Sciences | en |
dc.subject | hypothalamo-pituitary-adrenocortical (HPA) axis | en |
dc.subject | circadian rhythm | en |
dc.subject | nonlinear dynamics | en |
dc.subject | stability analysis | en |
dc.title | A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics | en |
dc.type | article | en |
dcterms.abstract | Јелиц, С; Савић Данка A; | |
dc.citation.volume | 1048 | |
dc.citation.spage | 430 | |
dc.citation.epage | 432 | |
dc.identifier.wos | 000233712300052 | |
dc.identifier.doi | 10.1196/annals.1342.055 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 16154968 | |
dc.description.other | 22nd International Biophysics Symposium, Oct 09-14, 2004, Belgrade, Serbia | en |
dc.identifier.scopus | 2-s2.0-25144448594 |
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