A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics
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Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another plausible explanation of the origin of this pattern: HPA just responds to an external pacemaker. A qualitative mathematical model is constructed wherein all the terms in the equations are physicochemically interpretable. Linear stability analysis shows that this system does not generate oscillations. Computer simulation yields oscillations that are the systems response to an external pulsing activator, implying that the observed pattern does not have to be an intrinsic property of this system.
Кључне речи:hypothalamo-pituitary-adrenocortical (HPA) axis / circadian rhythm / nonlinear dynamics / stability analysis
Извор:Annals of the New York Academy of Sciences, 2005, 1048, 430-432
- 22nd International Biophysics Symposium, Oct 09-14, 2004, Belgrade, Serbia
ISSN: 0077-8923 (print)