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dc.creatorKorićanac, Lela
dc.creatorTodorović, Danijela V.
dc.creatorPopović, Nataša M.
dc.creatorDemajo, Miroslav
dc.creatorRuždijić, Sabera
dc.creatorRistić-Fira, Aleksandra
dc.date.accessioned2018-03-03T14:09:33Z
dc.date.available2018-03-03T14:09:33Z
dc.date.issued2004
dc.identifier.issn0077-8923
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/6500
dc.description.abstractNovel antineoplastic agents, 8-chloroadenosine 3,5-monophosphate (8-Cl-cAMP) and tiazofurin (TR), have been shown to be effective against different malignant cells. Through specific mechanisms of action they modulate the cellular signal transduction pathway, thereby causing growth inhibition, cell differentiation, and apoptosis. The aim of this work was the in vitro study of either 8-Cl-cAMP or TR effects on B16/F10 and B16/C3 mouse melanoma cell growth and cell death. Significant cell growth inhibition was obtained after the application of 8-Cl-cAMP or TR. The presence and number of apoptotic cells was evaluated using agarose gel electrophoresis and flow cytometry. The number of apoptotic nuclei, after treatment with antineoplastic agents, did not significantly change in B16/F10 cells, although it did show a significant increase in B16/C3 cells. The expression of c-myc did not significantly change in B16/F10 cells after treatment with 8-Cl-cAMP or TR. The same results were obtained in B16/C3 cells after treatment with 8-Cl-cAMP. The level of c-myc expression showed a significant increase in B16/C3 cells after treatment with TR. Concerning the effects that the analyzed agents exhibited on melanoma cells and other cancer cells, further preclinical studies of these drugs will potentially lead to better understanding of the molecular mechanisms of their action and finally more efficient therapeutic approaches to malignant diseases.en
dc.rightsrestrictedAccessen
dc.sourceAnnals of the New York Academy of Sciencesen
dc.subjectmelanomaen
dc.subjectapoptosisen
dc.subject8-Cl-cAMPen
dc.subjecttiazofurinen
dc.titleInhibition of B16 mouse melanoma cell growth and induction of apoptotic cell death with 8-chloroadenosine-3 5,-monophosphate and tiazofurinen
dc.typearticleen
dcterms.abstractКорићанац Лела; Ристић-Фира Aлександра; Поповић Наташа; Тодоровиц, ДВ; Демајо, МA; Руздијиц, СД;
dc.citation.volume1030
dc.citation.spage384
dc.citation.epage392
dc.identifier.wos000228128100047
dc.identifier.doi10.1196/annals.1329.048
dc.citation.rankM21
dc.identifier.pmid15659821
dc.description.otherConference on Signal Transduction Pathways, Chromatin Structures and Gene Expression Mechanisms as Therapeutic Targets (Science Week 2004), Jan 25-31, 2004, Luxembourg, Luxembourgen
dc.identifier.scopus2-s2.0-15044352169


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