Combined effects of lipoprotein lipase and apolipoprotein E polymorphisms on serum lipid levels in Serbian population
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Lipoprotein lipase (LPL) gene mutations might be one of genetic factors for the development of hyperlipoproteinemia in apoE2/2 homozygotes and E2 heterozygotes. Fasting serum lipids and analyses of the LPL gene Asn291Ser polymorphism and apolipoprotein (apo) E common polymorphism were performed in 201 healthy subjects. An interaction between the LPL/apoE DNA polymorphisms on serum total cholesterol (TC) and triglycerides (TG) variation was found. Individuals carrying the E2+/Ser291 allele had significantly higher mean TC (P LT 0.01) and TG (P LT 0.05) and lower high density lipoprotein cholesterol (HDLC) (P LT 0.05) compared with E2+/ Asn291. The results of this study demonstrate relationship between LPL and apoE DNA polymorphism. and serum lipid levels.
- EUROMEDLAB 2003: 15th IFCC/FESCC European Congress of Clinical Chemistry and Laboratory Medicine, Proceedings, Jun 01-05, 2003, Barcelona, Spain