Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies
2014
Аутори
Pagano, GiovanniTalamanca, Annarita Aiello
Castello, Giuseppe
Cordero, Mario D.
d'Ischia, Marco
Gadaleta, Maria Nicola
Pallardo, Federico V.
Petrović, Sandra
Tiano, Luca
Zatterale, Adriana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of oxidative stress (OS) have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders. We attempt to review broad-ranging pathologies that involvemitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage. The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review. The relevance of OS and MDF in di...fferent pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients.
Извор:
Oxidative Medicine and Cellular Longevity, 2014, 2014, 541230-Финансирање / пројекти:
- FIRB-MERIT [RBNE08HWLZ_012]
DOI: 10.1155/2014/541230
ISSN: 1942-0900; 1942-0994
PubMed: 24876913
WoS: 000336127800001
Scopus: 2-s2.0-84901933198
Колекције
Институција/група
VinčaTY - JOUR AU - Pagano, Giovanni AU - Talamanca, Annarita Aiello AU - Castello, Giuseppe AU - Cordero, Mario D. AU - d'Ischia, Marco AU - Gadaleta, Maria Nicola AU - Pallardo, Federico V. AU - Petrović, Sandra AU - Tiano, Luca AU - Zatterale, Adriana PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6007 AB - Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of oxidative stress (OS) have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders. We attempt to review broad-ranging pathologies that involvemitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage. The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review. The relevance of OS and MDF in different pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients. T2 - Oxidative Medicine and Cellular Longevity T1 - Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies VL - 2014 SP - 541230 DO - 10.1155/2014/541230 ER -
@article{ author = "Pagano, Giovanni and Talamanca, Annarita Aiello and Castello, Giuseppe and Cordero, Mario D. and d'Ischia, Marco and Gadaleta, Maria Nicola and Pallardo, Federico V. and Petrović, Sandra and Tiano, Luca and Zatterale, Adriana", year = "2014", abstract = "Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of oxidative stress (OS) have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders. We attempt to review broad-ranging pathologies that involvemitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage. The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review. The relevance of OS and MDF in different pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients.", journal = "Oxidative Medicine and Cellular Longevity", title = "Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies", volume = "2014", pages = "541230", doi = "10.1155/2014/541230" }
Pagano, G., Talamanca, A. A., Castello, G., Cordero, M. D., d'Ischia, M., Gadaleta, M. N., Pallardo, F. V., Petrović, S., Tiano, L.,& Zatterale, A.. (2014). Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies. in Oxidative Medicine and Cellular Longevity, 2014, 541230. https://doi.org/10.1155/2014/541230
Pagano G, Talamanca AA, Castello G, Cordero MD, d'Ischia M, Gadaleta MN, Pallardo FV, Petrović S, Tiano L, Zatterale A. Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies. in Oxidative Medicine and Cellular Longevity. 2014;2014:541230. doi:10.1155/2014/541230 .
Pagano, Giovanni, Talamanca, Annarita Aiello, Castello, Giuseppe, Cordero, Mario D., d'Ischia, Marco, Gadaleta, Maria Nicola, Pallardo, Federico V., Petrović, Sandra, Tiano, Luca, Zatterale, Adriana, "Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies" in Oxidative Medicine and Cellular Longevity, 2014 (2014):541230, https://doi.org/10.1155/2014/541230 . .