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dc.creatorMilovanović, Petar
dc.creatorRakočević, Zlatko Lj.
dc.creatorDjonic, Danijela
dc.creatorŽivković, Vladimir
dc.creatorHahn, Michael
dc.creatorNikolic, Slobodan
dc.creatorAmling, Michael
dc.creatorBusse, Bjoern
dc.creatorĐurić, Marija
dc.date.accessioned2018-03-02T00:09:28Z
dc.date.available2018-03-02T00:09:28Z
dc.date.issued2014
dc.identifier.issn0531-5565
dc.identifier.issn1873-6815
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/6001
dc.description.abstractTo unravel the origins of decreased bone strength in the superolateral femoral neck, we assessed bone structural features across multiple length scales at this cortical fracture initiating region in postmenopausal women with hip fracture and in aged-matched controls. Our combined methodological approach encompassed atomic force microscopy (AFM) characterization of cortical bone nano-structure, assessment of mineral content/distribution via quantitative backscattered electron imaging (qBEI), measurement of bone material properties by reference point indentation, aswell as evaluation of cortical micro-architecture and osteocyte lacunar density. Our findings revealed a wide range of differences between the fracture group and the controls, suggesting a number of detrimental changes at various levels of cortical bone hierarchical organization that may render bone fragile. Namely, mineral crystals at external cortical bone surfaces of the fracture group were larger (65.22 nm +/- 41.21 nm vs. 36.75 nm +/- 18.49 nm, p LT 0.001), and a shift to a higher mineral content and more homogenous mineralization profile as revealed via qBEI were found in the bone matrix of the fracture group. Fracture cases showed nearly 35% higher cortical porosity and showed significantly reduced osteocyte lacunar density compared to controls (226 +/- 27 vs. 247 +/- 32 #/mm2, p= 0.05). Along with increased crystal size, a shift towards higher mineralization and a tendency to increased cortical porosity and reduced osteocyte lacunar number delineate that cortical bone of the superolateral femoral neck bears distinct signs of fragility at various levels of its structural organization. These results contribute to the understanding of hierarchical bone structure changes in age-related fragility. (C) 2014 Elsevier Inc. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45005/RS//
dc.relationSouth-East-Europe Cooperation of University Medical Center Hamburg-Eppendorf, Emmy Noether program (DFG) [BU 2562/2-1], European Federation for Experimental Morphology (EFEM Travel)
dc.rightsrestrictedAccessen
dc.sourceExperimental Gerontologyen
dc.subjectBone fragilityen
dc.subjectHip fractureen
dc.subjectAgingen
dc.subjectHierarchical structureen
dc.subjectAtomic force microscopyen
dc.subjectQuantitative backscatter electron microscopyen
dc.titleNano-structural, compositional and micro-architectural signs of cortical bone fragility at the superolateral femoral neck in elderly hip fracture patients vs. healthy aged controlsen
dc.typearticleen
dcterms.abstractAмлинг, Мицхаел; Буссе, Бјоерн; Дјуриц, Марија; Николиц, Слободан; Миловановиц, Петар; Дјониц, Данијела; Зивковиц, Владимир; Хахн, Мицхаел; Ракочевић Златко Љ.;
dc.citation.volume55
dc.citation.spage19
dc.citation.epage28
dc.identifier.wos000335929300003
dc.identifier.doi10.1016/j.exger.2014.03.001
dc.citation.rankM21
dc.identifier.pmid24614625
dc.identifier.scopus2-s2.0-84896513938


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