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In vivo effects of 17 beta-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart
dc.creator | Obradović, Milan M. | |
dc.creator | Stewart, Alan J. | |
dc.creator | Pitt, Samantha J. | |
dc.creator | Labudović-Borović, Milica | |
dc.creator | Sudar, Emina | |
dc.creator | Petrovic, Voin | |
dc.creator | Zafirović, Sonja | |
dc.creator | Maravić-Stojković, Vera | |
dc.creator | Vasić, Vesna M. | |
dc.creator | Isenović, Esma R. | |
dc.date.accessioned | 2018-03-02T00:08:26Z | |
dc.date.available | 2018-03-02T00:08:26Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0303-7207 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/5989 | |
dc.description.abstract | In this study the in vivo effects of estradiol in regulating Na+/K+-ATPase function in rat heart was studied. Adult male Wistar rats were treated with estradiol (40 mu g/kg, i.p.) and after 24 h the animals were sacrificed and the heart excised. Following estradiol administration, cardiac Na+/K(+)ATPase activity, expression of the alpha l subunit, and phosphorylation of the al subunit were significantly increased. These animals also had significantly decreased levels of digoxin-like immunoreactive factor(s). Na+ levels were also significantly reduced but to a level that was still within the normal physiological range, highlighting the ability of the Na+/K+-ATPase to balance the ionic composition following treatment with estradiol. Estradiol treated rats also showed increased phosphorylation of protein kinase B (Akt), and extracellular-signal-regulated kinase 1/2 (ERK1/2). We therefore suggest a role for Akt and/or ERK1/2 in estradiol-mediated regulation of cardiac Na+/K+-ATPase expression and activity in rat heart. (C) 2014 Elsevier Ireland Ltd. All rights reserved. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS// | |
dc.rights | restrictedAccess | en |
dc.source | Molecular and Cellular Endocrinology | en |
dc.subject | Estradiol | en |
dc.subject | Sodium potassium adenosine-triphosphatase | en |
dc.subject | Protein kinase B | en |
dc.subject | Extracellular-signal-regulated kinase 1/2 | en |
dc.title | In vivo effects of 17 beta-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart | en |
dc.type | article | en |
dcterms.abstract | Стеwарт, Aлан Ј.; Питт, Самантха Ј.; Лабудовиц-Боровиц, Милица; Петровиц, Воин; Маравиц-Стојковиц, Вера; Обрадовић Милан; Судар Емина; Зафировић Соња; Васић Весна М; Исеновић Есма; | |
dc.citation.volume | 388 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 58 | |
dc.citation.epage | 68 | |
dc.identifier.wos | 000335630600007 | |
dc.identifier.doi | 10.1016/j.mce.2014.03.005 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 24662727 | |
dc.identifier.scopus | 2-s2.0-84897483356 |
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