In vivo effects of 17 beta-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart
Нема приказа
Аутори
Obradović, Milan M.Stewart, Alan J.
Pitt, Samantha J.
Labudović-Borović, Milica
Sudar, Emina
Petrovic, Voin
Zafirović, Sonja
Maravić-Stojković, Vera
Vasić, Vesna M.
Isenović, Esma R.
Чланак у часопису
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Приказ свих података о документуАпстракт
In this study the in vivo effects of estradiol in regulating Na+/K+-ATPase function in rat heart was studied. Adult male Wistar rats were treated with estradiol (40 mu g/kg, i.p.) and after 24 h the animals were sacrificed and the heart excised. Following estradiol administration, cardiac Na+/K(+)ATPase activity, expression of the alpha l subunit, and phosphorylation of the al subunit were significantly increased. These animals also had significantly decreased levels of digoxin-like immunoreactive factor(s). Na+ levels were also significantly reduced but to a level that was still within the normal physiological range, highlighting the ability of the Na+/K+-ATPase to balance the ionic composition following treatment with estradiol. Estradiol treated rats also showed increased phosphorylation of protein kinase B (Akt), and extracellular-signal-regulated kinase 1/2 (ERK1/2). We therefore suggest a role for Akt and/or ERK1/2 in estradiol-mediated regulation of cardiac Na+/K+-ATPase express...ion and activity in rat heart. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Кључне речи:
Estradiol / Sodium potassium adenosine-triphosphatase / Protein kinase B / Extracellular-signal-regulated kinase 1/2Извор:
Molecular and Cellular Endocrinology, 2014, 388, 1-2, 58-68Финансирање / пројекти:
DOI: 10.1016/j.mce.2014.03.005
ISSN: 0303-7207
PubMed: 24662727
WoS: 000335630600007
Scopus: 2-s2.0-84897483356
Колекције
Институција/група
VinčaTY - JOUR AU - Obradović, Milan M. AU - Stewart, Alan J. AU - Pitt, Samantha J. AU - Labudović-Borović, Milica AU - Sudar, Emina AU - Petrovic, Voin AU - Zafirović, Sonja AU - Maravić-Stojković, Vera AU - Vasić, Vesna M. AU - Isenović, Esma R. PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5989 AB - In this study the in vivo effects of estradiol in regulating Na+/K+-ATPase function in rat heart was studied. Adult male Wistar rats were treated with estradiol (40 mu g/kg, i.p.) and after 24 h the animals were sacrificed and the heart excised. Following estradiol administration, cardiac Na+/K(+)ATPase activity, expression of the alpha l subunit, and phosphorylation of the al subunit were significantly increased. These animals also had significantly decreased levels of digoxin-like immunoreactive factor(s). Na+ levels were also significantly reduced but to a level that was still within the normal physiological range, highlighting the ability of the Na+/K+-ATPase to balance the ionic composition following treatment with estradiol. Estradiol treated rats also showed increased phosphorylation of protein kinase B (Akt), and extracellular-signal-regulated kinase 1/2 (ERK1/2). We therefore suggest a role for Akt and/or ERK1/2 in estradiol-mediated regulation of cardiac Na+/K+-ATPase expression and activity in rat heart. (C) 2014 Elsevier Ireland Ltd. All rights reserved. T2 - Molecular and Cellular Endocrinology T1 - In vivo effects of 17 beta-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart VL - 388 IS - 1-2 SP - 58 EP - 68 DO - 10.1016/j.mce.2014.03.005 ER -
@article{ author = "Obradović, Milan M. and Stewart, Alan J. and Pitt, Samantha J. and Labudović-Borović, Milica and Sudar, Emina and Petrovic, Voin and Zafirović, Sonja and Maravić-Stojković, Vera and Vasić, Vesna M. and Isenović, Esma R.", year = "2014", abstract = "In this study the in vivo effects of estradiol in regulating Na+/K+-ATPase function in rat heart was studied. Adult male Wistar rats were treated with estradiol (40 mu g/kg, i.p.) and after 24 h the animals were sacrificed and the heart excised. Following estradiol administration, cardiac Na+/K(+)ATPase activity, expression of the alpha l subunit, and phosphorylation of the al subunit were significantly increased. These animals also had significantly decreased levels of digoxin-like immunoreactive factor(s). Na+ levels were also significantly reduced but to a level that was still within the normal physiological range, highlighting the ability of the Na+/K+-ATPase to balance the ionic composition following treatment with estradiol. Estradiol treated rats also showed increased phosphorylation of protein kinase B (Akt), and extracellular-signal-regulated kinase 1/2 (ERK1/2). We therefore suggest a role for Akt and/or ERK1/2 in estradiol-mediated regulation of cardiac Na+/K+-ATPase expression and activity in rat heart. (C) 2014 Elsevier Ireland Ltd. All rights reserved.", journal = "Molecular and Cellular Endocrinology", title = "In vivo effects of 17 beta-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart", volume = "388", number = "1-2", pages = "58-68", doi = "10.1016/j.mce.2014.03.005" }
Obradović, M. M., Stewart, A. J., Pitt, S. J., Labudović-Borović, M., Sudar, E., Petrovic, V., Zafirović, S., Maravić-Stojković, V., Vasić, V. M.,& Isenović, E. R.. (2014). In vivo effects of 17 beta-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart. in Molecular and Cellular Endocrinology, 388(1-2), 58-68. https://doi.org/10.1016/j.mce.2014.03.005
Obradović MM, Stewart AJ, Pitt SJ, Labudović-Borović M, Sudar E, Petrovic V, Zafirović S, Maravić-Stojković V, Vasić VM, Isenović ER. In vivo effects of 17 beta-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart. in Molecular and Cellular Endocrinology. 2014;388(1-2):58-68. doi:10.1016/j.mce.2014.03.005 .
Obradović, Milan M., Stewart, Alan J., Pitt, Samantha J., Labudović-Borović, Milica, Sudar, Emina, Petrovic, Voin, Zafirović, Sonja, Maravić-Stojković, Vera, Vasić, Vesna M., Isenović, Esma R., "In vivo effects of 17 beta-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart" in Molecular and Cellular Endocrinology, 388, no. 1-2 (2014):58-68, https://doi.org/10.1016/j.mce.2014.03.005 . .