Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats

Abstract

Chronic isolation stress of adult rat males acted increasing gene expression of tyrosine hydroxylase (TH) and neuronal norepinephrine transporter (NET) in the right stellate ganglia, while vesicular monoamine transporter 2 (VMAT2) level remained unchanged. The stress decreased protein level of TH, as well as mRNA levels for NET and VMAT2 in the left stellate ganglia, but expressed no effect on protein levels of these two transporters. These results demonstrate asymmetry in noradrenegic genes in the right and left stellate ganglia during stress and provide molecular evidence to help explain the difference in response to the stress. (C) 2014 Elsevier B.V. All rights reserved.