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The expression of ACE, ACE2, AT1 and AT2 receptors in the heart of fructose fed ovariectomized rats-Effect of estradiol
dc.creator | Bundalo, Maja M. | |
dc.creator | Tepavčević, Snežana | |
dc.creator | Romić, Snježana Đ. | |
dc.creator | Korićanac, Goran | |
dc.creator | Živković, Maja | |
dc.creator | Stanković, Aleksandra | |
dc.date.accessioned | 2018-03-01T23:46:39Z | |
dc.date.available | 2018-03-01T23:46:39Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0008-6312 | |
dc.identifier.issn | 1421-9751 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/5741 | |
dc.description.abstract | Background: Heart disease or diabetes could be promoted in people who consume sugar. High dietary intake of fructose also increases risk for heart disease. The effects of fructose diet on metabolism, lipid profile and blood pressure are dependent of sex. Renin-angiotensin system (RAS) impairs insulin sensi- tivity, whereas hyperinsulinemia and insulin resistance promotes the development of cardiovascular dis- orders. We examined the effects of fructose rich diet (FRD) and estradiol (E2) on the expression of ACE, ACE2, AT1R and AT2R in the rat heart. Methods and Results: 21 day old female rats were divided in control group and FRD group. At two weeks before sacrifice, animals were ovariectomised and half of the FRD rats were subjected to E2 re- placement. FRD increased ACE (p<0.001) and AT1R (p<0.05) protein expression, while AT2R expression was decreased (p<0.05). ACE2 protein expression was unaltered. mRNA expression for AT1R was unal- tered, as assessed by qPCR. E2 treatment significantly decreased protein expression for ACE (p<0.001) and AT1R (p<0.01), while ACE2 (p<0.01) and AT2R (p<0.01) expression was increased. Effect of E2 treat- ment on AT1R gene expression was not statistically significant but showed trend toward lowering AT1R gene expression. We didn’t detected AT2R gene expression. Conclusion: FRD affects almost all components of the RAS in the rat heart.The increase of the ACE and AT1R protein expression and decrease of AT2R expression could be the the way that leads to the devel- opment of cardiovascular disorders. The E2 shows strong protective effect in FRD through reversion of the changes in RAS components expression. | en |
dc.rights | restrictedAccess | en |
dc.source | Cardiology | en |
dc.title | The expression of ACE, ACE2, AT1 and AT2 receptors in the heart of fructose fed ovariectomized rats-Effect of estradiol | en |
dc.type | conferenceObject | en |
dc.rights.license | ARR | |
dcterms.abstract | Живковић Маја; Станковић Aлександра; Тепавчевић Снежана; Бундало Маја; Корићанац Горан; Ромић Сњежана; | |
dc.citation.volume | 126 | |
dc.citation.issue | Suppl. 2 | |
dc.citation.spage | 353 | |
dc.citation.epage | 353 | |
dc.identifier.wos | 000326437200349 | |
dc.identifier.doi | 10.1159/000355890 | |
dc.citation.other | Suppl: 2 | |
dc.citation.rank | M23 | |
dc.type.version | publishedVersion | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_vinar_5741 |
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