Radiation synthesis, characterisation and antimicrobial application of novel copolymeric silver/poly(2-hydroxyethyl methacrylate/itaconic acid) nanocomposite hydrogels
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Silver nanoparticles were fabricated via in situ reduction of silver nitrate embedded in swollen P(HEMA/IA) hydrogel, using gamma radiolysis method. Copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), previously synthesised by gamma radiation for wound dressing application, were used as a carrier and a stabilising agent, while ethyl alcohol was used as a free radical scavenger. The influence of different P(HEMA/IA) hydrogels and silver salt concentrations on the size and distribution of nanoparticles was investigated. The Ag/P(HEMA/IA) nanocomposites were characterised by high resolution scanning electron microscopy, energy dispersive spectroscopy, wide-angle X-ray diffraction, UV-Vis spectroscopy and swelling measurements. Escherichia coli (Gram-negative bacterium), Staphylococcus aureus (Gram-positive bacterium) and Candida albicans (fungus) were used to prove the antimicrobial properties of Ag/P(HEMA/IA) nanocomposites. The inhibition kinetics o...f bacteria growth was investigated by measuring the colony-forming unit. The antimicrobial effectiveness of the Ag/P(HEMA/IA) hydrogel nanocomposite was demonstrated even at small silver concentrations. P(HEMA/IA) hydrogels containing nanosilver particles was found suitable to be used as wound dressing.
Кључне речи:Ag nanoparticles (AgNPs) / Gamma radiation / P(HEMA/IA) hydrogel / Antimicrobial activity
Извор:Polymer Bulletin, 2013, 70, 12, 3347-3357
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-172026)
ISSN: 0170-0839 (print); 1436-2449 (electronic)