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Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol
dc.creator | Bundalo, Maja M. | |
dc.creator | Živković, Maja | |
dc.creator | Tepavčević, Snežana | |
dc.creator | Ćulafić, Tijana | |
dc.creator | Korićanac, Goran | |
dc.creator | Stanković, Aleksandra | |
dc.date.accessioned | 2018-03-01T16:10:11Z | |
dc.date.available | 2018-03-01T16:10:11Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0018-5043 | |
dc.identifier.issn | 1439-4286 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/570 | |
dc.description.abstract | The renin-angiotensin system has been implicated in the development of metabolic syndrome and appears to be a key in the local tissue control of normal cardiac functions. Physiological concentrations of estrogens have been shown to be cardioprotective, especially against the damaging effects of fructose-rich diet. The aim of the study was to investigate the expression of the renin-angiotensin system molecules with potentially deleterious effect on the heart (angiotensin-converting enzyme and angiotensin II type 1 receptor) and those with potentially protective effects, (angiotensin-converting enzyme 2 and angiotensin II type 2 receptor), in ovariectomized fructose fed female rats with 17-estradiol replacement. Real-time PCR and Western blot analysis were used for quantification of gene and protein expression in the heart. Fructose diet increased the expression of angiotensin-converting enzyme and angiotensin II type 1 receptor and decreased the expression of angiotensin-converting enzyme 2 and angiotensin II type 2 receptor. On the other hand, estradiol replacement seems to undo fructose diet effects on cardiac renin-angiotensin system. Downregulation of angiotensin-converting enzyme and angiotensin II type 1 receptor, and reversion of expression of both potentially protective molecules, angiotensin-converting enzyme 2 and angiotensin II type 2 receptor, to the control level in cardiac tissue took place. Obtained results suggest that estradiol may reverse the harmful effect of fructose-rich diet on the expression of renin-angiotensin system molecules. These findings may also be important in further research of phenotypes like insulin resistance, metabolic syndrome, and following cardiovascular pathology in females. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS// | |
dc.rights | restrictedAccess | en |
dc.source | Hormone and Metabolic Research | en |
dc.subject | metabolic syndrome | en |
dc.subject | ovariectomy | en |
dc.subject | angiotensin converting enzyme | en |
dc.subject | angiotensin converting enzyme 2 | en |
dc.subject | angiotensin II type 1 receptor | en |
dc.subject | angiotensin II type 2 receptor | en |
dc.title | Fructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiol | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Живковић Маја; Тепавчевић Снежана; Корићанац Горан; Бундало Маја; Станковић Aлександра; Ћулафић Тијана; | |
dc.citation.volume | 47 | |
dc.citation.issue | 7 | |
dc.citation.spage | 521 | |
dc.citation.epage | 527 | |
dc.identifier.wos | 000355332200009 | |
dc.identifier.doi | 10.1055/s-0034-1394373 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 25369074 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-84946240884 |
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