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dc.creatorBundalo, Maja M.
dc.creatorŽivković, Maja
dc.creatorTepavčević, Snežana
dc.creatorĆulafić, Tijana
dc.creatorKorićanac, Goran
dc.creatorStanković, Aleksandra
dc.date.accessioned2018-03-01T16:10:11Z
dc.date.available2018-03-01T16:10:11Z
dc.date.issued2015
dc.identifier.issn0018-5043 (print)
dc.identifier.issn1439-4286 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/570
dc.description.abstractThe renin-angiotensin system has been implicated in the development of metabolic syndrome and appears to be a key in the local tissue control of normal cardiac functions. Physiological concentrations of estrogens have been shown to be cardioprotective, especially against the damaging effects of fructose-rich diet. The aim of the study was to investigate the expression of the renin-angiotensin system molecules with potentially deleterious effect on the heart (angiotensin-converting enzyme and angiotensin II type 1 receptor) and those with potentially protective effects, (angiotensin-converting enzyme 2 and angiotensin II type 2 receptor), in ovariectomized fructose fed female rats with 17-estradiol replacement. Real-time PCR and Western blot analysis were used for quantification of gene and protein expression in the heart. Fructose diet increased the expression of angiotensin-converting enzyme and angiotensin II type 1 receptor and decreased the expression of angiotensin-converting enzyme 2 and angiotensin II type 2 receptor. On the other hand, estradiol replacement seems to undo fructose diet effects on cardiac renin-angiotensin system. Downregulation of angiotensin-converting enzyme and angiotensin II type 1 receptor, and reversion of expression of both potentially protective molecules, angiotensin-converting enzyme 2 and angiotensin II type 2 receptor, to the control level in cardiac tissue took place. Obtained results suggest that estradiol may reverse the harmful effect of fructose-rich diet on the expression of renin-angiotensin system molecules. These findings may also be important in further research of phenotypes like insulin resistance, metabolic syndrome, and following cardiovascular pathology in females.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS//
dc.rightsrestrictedAccessen
dc.sourceHormone and Metabolic Researchen
dc.subjectmetabolic syndromeen
dc.subjectovariectomyen
dc.subjectangiotensin converting enzymeen
dc.subjectangiotensin converting enzyme 2en
dc.subjectangiotensin II type 1 receptoren
dc.subjectangiotensin II type 2 receptoren
dc.titleFructose-Rich Diet-Induced Changes in the Expression of the Renin Angiotensin System Molecules in the Heart of Ovariectomized Female Rats Could be Reversed by Estradiolen
dc.typearticleen
dcterms.abstractЖивковић Маја; Тепавчевић Снежана; Корићанац Горан; Бундало Маја; Станковић Aлександра; Ћулафић Тијана;
dc.citation.volume47
dc.citation.issue7
dc.citation.spage521
dc.citation.epage527
dc.identifier.wos000355332200009
dc.identifier.doi10.1055/s-0034-1394373
dc.citation.rankM23
dc.identifier.pmid25369074
dc.identifier.scopus2-s2.0-84946240884


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