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dc.creatorPejić, Snežana
dc.creatorKasapović, Jelena
dc.creatorTodorović, Ana
dc.creatorStojiljković, Vesna
dc.creatorGavrilović, Ljubica
dc.creatorPopović, Nataša M.
dc.creatorPajović, Snežana B.
dc.date.accessioned2018-03-01T23:43:31Z
dc.date.available2018-03-01T23:43:31Z
dc.date.issued2013
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/5705
dc.description.abstractObjective: To investigate whether antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. Study design: The material consisted of blood and endometrial tissue specimens from women diagnosed with endometrial polyps. Patients were divided into groups depending on the phase of the menstrual cycle - follicular or luteal - and the postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxide levels were compared among the phases and a linear regression model was used to evaluate the associations between hormones and antioxidant/oxidant variables. Results: In the blood of examined women, a significant difference in superoxide dismutase activity and lipid hydroperoxide levels was recorded among the phases. There was also a positive correlation between the estradiol concentration and superoxide dismutase. In polyp tissue, we recorded a phase-related difference in superoxide dismutase and glutathione peroxidase activities as well as in the lipid hydroperoxide levels. A negative correlation was observed between FSH/LH and glutathione peroxidase, and between LH and superoxide dismutase. Conclusion: Antioxidant enzymes and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones during the menstrual cycle and after the menopause, pointing to a role of the observed relationship in polyp etiology. (C) 2013 Elsevier Ireland Ltd. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41027/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41022/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173041/RS//
dc.rightsrestrictedAccessen
dc.sourceEuropean Journal of Obstetrics Gynecology and Reproductive Biologyen
dc.subjectAntioxidant enzymesen
dc.subjectSex hormonesen
dc.subjectEndometrial polypen
dc.titleAntioxidant enzymes in women with endometrial polyps: relation with sex hormonesen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractКасаповић Јелена; Тодоровић Aна; Стојиљковић Весна; Пејић Снежана; Поповић Наташа; Пајовиц, Снезана Б.; Гавриловић Љубица;
dc.citation.volume170
dc.citation.issue1
dc.citation.spage241
dc.citation.epage246
dc.identifier.wos000325122000048
dc.identifier.doi10.1016/j.ejogrb.2013.06.024
dc.citation.rankM23
dc.identifier.pmid23871381
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-84883054272


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