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dc.creatorBabić Božović, Ivana
dc.creatorStanković, Aleksandra
dc.creatorŽivković, Maja
dc.creatorVraneković, Jadranka
dc.creatorKapović, Miljenko
dc.creatorBrajenović-Milić, Bojana
dc.date.accessioned2018-03-01T16:09:39Z
dc.date.available2018-03-01T16:09:39Z
dc.date.issued2015
dc.identifier.issn1932-6203
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/564
dc.description.abstractDown syndrome (DS, also known as trisomy 21) most often results from chromosomal nondisjunction during oogenesis. Numerous studies sustain a causal link between global DNA hypomethylation and genetic instability. It has been suggested that DNA hypomethylation might affect the structure and dynamics of chromatin regions that are critical for chromosome stability and segregation, thus favouring chromosomal nondisjunction during meiosis. Maternal global DNA hypomethylation has not yet been analyzed as a potential risk factor for chromosome 21 nondisjunction. This study aimed to asses the risk for DS in association with maternal global DNA methylation and the impact of endogenous and exogenous factors that reportedly influence DNA methylation status. Global DNA methylation was analyzed in peripheral blood lymphocytes by quantifying LINE-1 methylation using the MethyLight method. Levels of global DNA methylation were significantly lower among mothers of children with maternally derived trisomy 21 than among control mothers (P = 0.000). The combination of MTHFR C677T genotype and diet significantly influenced global DNA methylation (R-2 = 4.5%, P = 0.046). The lowest values of global DNA methylation were observed in mothers with MTHFR 677 CT+TT genotype and low dietary folate. Although our findings revealed an association between maternal global DNA hypomethylation and trisomy 21 of maternal origin, further progress and final conclusions regarding the role of global DNA methylation and the occurrence of trisomy 21 are facing major challenges.en
dc.relationUniversity of Rijeka, Rijeka, Croatia [13.06.1.2.38]
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcePLOS Oneen
dc.titleAltered LINE-1 Methylation in Mothers of Children with Down Syndromeen
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractКаповиц, Миљенко; Вранековиц, Јадранка; Бабиц Бозовиц, Ивана; Живковић Маја; Брајеновиц-Милиц, Бојана; Станковић Aлександра;
dc.citation.volume10
dc.citation.issue5
dc.identifier.wos000355185600082
dc.identifier.doi10.1371/journal.pone.0127423
dc.citation.otherArticle Number: e0127423
dc.citation.rankM21
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-84957549144


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