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dc.creatorPerović, Vladimir R.
dc.date.accessioned2018-03-01T23:36:20Z
dc.date.available2018-03-01T23:36:20Z
dc.date.issued2013
dc.identifier.issn0259-9791 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5622
dc.description.abstractThe highly pathogenic avian influenza virus (HPAIV) A subtype H5N1 is causing threat to human health over the years. Phylogenetic analysis is an important tool for analyzing the evolution of influenza. A novel phylogenetic algorithm based on a new protein distance measure derived from the informational spectrum method (ISM) has been presented. The new phylogenetic approach allows assessment of functional evolution of protein sequences. The new ISM-based phylogenetic approach has been found to overcome some drawbacks of other phylogenetic approaches, particularly concerning sensitivity to a single mutation, deletion and the position of the mutation. The ISM-based approach applied to hemagglutinin subunit 1 protein (HA1) of HPAIV A subtype H5N1 viruses in Egypt between 2006 and 2011, revealed clear clustering in two groups, with one growing group of H5N1 viruses after 2009 with increased number of human infections with H5N1. Four group-specific mutations are identified which are important for increased human tropism and the pandemic potential.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173001/RS//
dc.rightsrestrictedAccessen
dc.sourceJournal of Mathematical Chemistryen
dc.subjectProtein sequenceen
dc.subjectPhylogenetic analysisen
dc.subjectH5N1 influenza virusen
dc.subjectElectron-ion interaction potentialen
dc.subjectInformational spectrum methoden
dc.titleNovel algorithm for phylogenetic analysis of proteins: application to analysis of the evolution of H5N1 influenza virusesen
dc.typearticleen
dcterms.abstractПеровић Владимир;
dc.citation.volume51
dc.citation.issue8
dc.citation.spage2238
dc.citation.epage2255
dc.identifier.wos000322902800019
dc.identifier.doi10.1007/s10910-013-0212-1
dc.citation.rankM22
dc.identifier.scopus2-s2.0-84883792515


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