Accurate Diagnostics of Ataxia-Telangiectasia Cellular Phenotype By Employing in Vitro Lymphocyte Radiosensitivity Testing
2013
Аутори
Vujić, DraganaPetrović, Sandra
Leskovac, Andreja
Joksić, Ivana
Filipović, Jelena G.
Valenta-Šobot, Ana
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
In this paper we present the data of lymphocyte radiosensitivity testing used for characterization of radiosensitive cellular phenotype and diagnostics of ataxia-telangiectasia disease. We point out the advantage of lymphocyte micronucleus test (CBMN) over other cellular tests for assessment of radiosensitivity: the first advantage of CBMN is that primary patient cells are used (less than 1 ml), the second one is that the results of testing are obtained within 3 days and there is no need for establishing a patient-derived cell line, which requires additional time and application of more expensive methods. The third advantage of CBMN method is that it gives information about proliferative ability of cells, which can recognize dysfunctional ataxia-telangiectasia mutated protein. The results are fast and accurate in diagnostics of ataxia-telagiectasia diseases.
Кључне речи:
ataxia-telagiectasia / radiosensitity testing / diagnosticsИзвор:
Nuclear technology and radiation protection, 2013, 28, 2, 221-224Финансирање / пројекти:
- Радиосензитивност хуманог генома (RS-173046)
DOI: 10.2298/NTRP1302221V
ISSN: 1451-3994
WoS: 000322101900014
Scopus: 2-s2.0-84881018830
Колекције
Институција/група
VinčaTY - JOUR AU - Vujić, Dragana AU - Petrović, Sandra AU - Leskovac, Andreja AU - Joksić, Ivana AU - Filipović, Jelena G. AU - Valenta-Šobot, Ana PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5595 AB - In this paper we present the data of lymphocyte radiosensitivity testing used for characterization of radiosensitive cellular phenotype and diagnostics of ataxia-telangiectasia disease. We point out the advantage of lymphocyte micronucleus test (CBMN) over other cellular tests for assessment of radiosensitivity: the first advantage of CBMN is that primary patient cells are used (less than 1 ml), the second one is that the results of testing are obtained within 3 days and there is no need for establishing a patient-derived cell line, which requires additional time and application of more expensive methods. The third advantage of CBMN method is that it gives information about proliferative ability of cells, which can recognize dysfunctional ataxia-telangiectasia mutated protein. The results are fast and accurate in diagnostics of ataxia-telagiectasia diseases. T2 - Nuclear technology and radiation protection T1 - Accurate Diagnostics of Ataxia-Telangiectasia Cellular Phenotype By Employing in Vitro Lymphocyte Radiosensitivity Testing VL - 28 IS - 2 SP - 221 EP - 224 DO - 10.2298/NTRP1302221V ER -
@article{ author = "Vujić, Dragana and Petrović, Sandra and Leskovac, Andreja and Joksić, Ivana and Filipović, Jelena G. and Valenta-Šobot, Ana", year = "2013", abstract = "In this paper we present the data of lymphocyte radiosensitivity testing used for characterization of radiosensitive cellular phenotype and diagnostics of ataxia-telangiectasia disease. We point out the advantage of lymphocyte micronucleus test (CBMN) over other cellular tests for assessment of radiosensitivity: the first advantage of CBMN is that primary patient cells are used (less than 1 ml), the second one is that the results of testing are obtained within 3 days and there is no need for establishing a patient-derived cell line, which requires additional time and application of more expensive methods. The third advantage of CBMN method is that it gives information about proliferative ability of cells, which can recognize dysfunctional ataxia-telangiectasia mutated protein. The results are fast and accurate in diagnostics of ataxia-telagiectasia diseases.", journal = "Nuclear technology and radiation protection", title = "Accurate Diagnostics of Ataxia-Telangiectasia Cellular Phenotype By Employing in Vitro Lymphocyte Radiosensitivity Testing", volume = "28", number = "2", pages = "221-224", doi = "10.2298/NTRP1302221V" }
Vujić, D., Petrović, S., Leskovac, A., Joksić, I., Filipović, J. G.,& Valenta-Šobot, A.. (2013). Accurate Diagnostics of Ataxia-Telangiectasia Cellular Phenotype By Employing in Vitro Lymphocyte Radiosensitivity Testing. in Nuclear technology and radiation protection, 28(2), 221-224. https://doi.org/10.2298/NTRP1302221V
Vujić D, Petrović S, Leskovac A, Joksić I, Filipović JG, Valenta-Šobot A. Accurate Diagnostics of Ataxia-Telangiectasia Cellular Phenotype By Employing in Vitro Lymphocyte Radiosensitivity Testing. in Nuclear technology and radiation protection. 2013;28(2):221-224. doi:10.2298/NTRP1302221V .
Vujić, Dragana, Petrović, Sandra, Leskovac, Andreja, Joksić, Ivana, Filipović, Jelena G., Valenta-Šobot, Ana, "Accurate Diagnostics of Ataxia-Telangiectasia Cellular Phenotype By Employing in Vitro Lymphocyte Radiosensitivity Testing" in Nuclear technology and radiation protection, 28, no. 2 (2013):221-224, https://doi.org/10.2298/NTRP1302221V . .