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dc.creatorKorićanac, Lela
dc.creatorŽakula, Jelena
dc.creatorKeta, Otilija D.
dc.creatorCirrone, Giuseppe Antonio Pablo
dc.creatorCuttone, Giacomo
dc.creatorRistić-Fira, Aleksandra
dc.creatorPetrović, Ivan M.
dc.date.accessioned2018-03-01T23:33:50Z
dc.date.available2018-03-01T23:33:50Z
dc.date.issued2013
dc.identifier.issn1451-3994 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/123456789/5593
dc.description.abstractThis study was conducted in order to evaluate the ability of carbon ions to induce DNA double-strand breaks and apoptosis in the radio-resistant human HTB140 melanoma cells. The cells were irradiated with C-12 ions having the linear energy transfer of 258 keV/mu m. Irradiations were performed in the dose range from 2 to 16 Gy. Induction of DNA double-strand breaks was evaluated 2 hour after irradiation through expression of gamma H2AX protein. Increased level of gamma H2AX detected in irradiated samples was especially high after irradiation with 12 and 16 Gy. Dose dependent increase of apoptosis was detected 48 hour after irradiation by flow-cytometry, with the maximum value of 20.4% after irradiation with 16 Gy, and the apoptotic index of 9.3. Pro-apoptotic effects of carbon ion beams were confirmed by changes of key molecules of the mitochondrial apoptotic pathway, p53 protein expression, Bax/Bcl-2 ratio and caspase-3 activation.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173046/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171019/RS//
dc.relationIstituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Catania, Italy
dc.rightsopenAccessen
dc.sourceNuclear technology and radiation protectionen
dc.subjectmelanomaen
dc.subjectcarbon ionen
dc.subjectapoptosisen
dc.subjectp53en
dc.subjectBax/Bcl-2 ratioen
dc.subjectcaspase-3en
dc.titleCarbon Ions Induce DNA Double Strand Breaks and Apoptosis in Htb140 Melanoma Cellsen
dc.typearticleen
dcterms.abstractКета, Отилија; Корићанац Лела; Жакула Јелена; Цирроне, Пабло; Цуттоне, Гиацомо; Ристић-Фира Aлександра; Петровић Иван;
dc.citation.volume28
dc.citation.issue2
dc.citation.spage195
dc.citation.epage203
dc.identifier.wos000322101900011
dc.identifier.doi10.2298/NTRP1302195K
dc.citation.rankM23
dc.identifier.scopus2-s2.0-84881000946
dc.identifier.fulltexthttp://vinar.rcub.bg.ac.rs/bitstream/handle/123456789/5593/1451-39941302195K.pdf


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