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dc.creatorČolović, Božana M.
dc.creatorMilivojević, Dušan
dc.creatorBabić-Stojić Branka S.
dc.creatorJokanović, Vukoman R.
dc.date.accessioned2018-03-01T23:23:26Z
dc.date.available2018-03-01T23:23:26Z
dc.date.issued2013
dc.identifier.issn0350-820X (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5473
dc.description.abstractRelease kinetics of tigecycline, a potential antibiotic in treatment of osteomyelitis, from calcium hydroxyapatite (CHA), as one of the most important ceramic materials in bone tissue engineering, was investigated in this study. Tigecycline, in solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets using two different pressures. These tablets were immersed in a phosphate-buffered saline solution and tigecycline release was measured by a UV-VIS spectrophotometer. The total release time was 5 or 28 days, depending on the pressure applied during compression. It was shown that there is a close relationship between pore sizes and drug release rate. The drug release kinetics was interpreted on the base of pore sizes and pore size distribution.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.rightsopenAccessen
dc.sourceScience of Sinteringen
dc.subjectHydroxyapatiteen
dc.subjectPore geometryen
dc.subjectDrug releaseen
dc.titlePore Geometry of Ceramic Device: the Key Factor of Drug Release Kineticsen
dc.typearticleen
dcterms.abstractЈокановић Вукоман Р.; Чоловић Божана; Миливојевић Душан; Бабић-Стојић Бранка С.;
dc.citation.volume45
dc.citation.issue1
dc.citation.spage107
dc.citation.epage116
dc.identifier.wos000318150200011
dc.identifier.doi10.2298/SOS1301107C
dc.citation.rankM23
dc.identifier.scopus2-s2.0-84877711467
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/13406/5469.pdf


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