Pore Geometry of Ceramic Device: the Key Factor of Drug Release Kinetics
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Release kinetics of tigecycline, a potential antibiotic in treatment of osteomyelitis, from calcium hydroxyapatite (CHA), as one of the most important ceramic materials in bone tissue engineering, was investigated in this study. Tigecycline, in solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets using two different pressures. These tablets were immersed in a phosphate-buffered saline solution and tigecycline release was measured by a UV-VIS spectrophotometer. The total release time was 5 or 28 days, depending on the pressure applied during compression. It was shown that there is a close relationship between pore sizes and drug release rate. The drug release kinetics was interpreted on the base of pore sizes and pore size distribution.
Кључне речи:
Hydroxyapatite / Pore geometry / Drug releaseИзвор:
Science of Sintering, 2013, 45, 1, 107-116Финансирање / пројекти:
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.2298/SOS1301107C
ISSN: 0350-820X
WoS: 000318150200011
Scopus: 2-s2.0-84877711467
Институција/група
VinčaTY - JOUR AU - Čolović, Božana M. AU - Milivojević, Dušan AU - Babić-Stojić, Branka S. AU - Jokanović, Vukoman R. PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5473 AB - Release kinetics of tigecycline, a potential antibiotic in treatment of osteomyelitis, from calcium hydroxyapatite (CHA), as one of the most important ceramic materials in bone tissue engineering, was investigated in this study. Tigecycline, in solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets using two different pressures. These tablets were immersed in a phosphate-buffered saline solution and tigecycline release was measured by a UV-VIS spectrophotometer. The total release time was 5 or 28 days, depending on the pressure applied during compression. It was shown that there is a close relationship between pore sizes and drug release rate. The drug release kinetics was interpreted on the base of pore sizes and pore size distribution. T2 - Science of Sintering T1 - Pore Geometry of Ceramic Device: the Key Factor of Drug Release Kinetics VL - 45 IS - 1 SP - 107 EP - 116 DO - 10.2298/SOS1301107C ER -
@article{ author = "Čolović, Božana M. and Milivojević, Dušan and Babić-Stojić, Branka S. and Jokanović, Vukoman R.", year = "2013", abstract = "Release kinetics of tigecycline, a potential antibiotic in treatment of osteomyelitis, from calcium hydroxyapatite (CHA), as one of the most important ceramic materials in bone tissue engineering, was investigated in this study. Tigecycline, in solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets using two different pressures. These tablets were immersed in a phosphate-buffered saline solution and tigecycline release was measured by a UV-VIS spectrophotometer. The total release time was 5 or 28 days, depending on the pressure applied during compression. It was shown that there is a close relationship between pore sizes and drug release rate. The drug release kinetics was interpreted on the base of pore sizes and pore size distribution.", journal = "Science of Sintering", title = "Pore Geometry of Ceramic Device: the Key Factor of Drug Release Kinetics", volume = "45", number = "1", pages = "107-116", doi = "10.2298/SOS1301107C" }
Čolović, B. M., Milivojević, D., Babić-Stojić, B. S.,& Jokanović, V. R.. (2013). Pore Geometry of Ceramic Device: the Key Factor of Drug Release Kinetics. in Science of Sintering, 45(1), 107-116. https://doi.org/10.2298/SOS1301107C
Čolović BM, Milivojević D, Babić-Stojić BS, Jokanović VR. Pore Geometry of Ceramic Device: the Key Factor of Drug Release Kinetics. in Science of Sintering. 2013;45(1):107-116. doi:10.2298/SOS1301107C .
Čolović, Božana M., Milivojević, Dušan, Babić-Stojić, Branka S., Jokanović, Vukoman R., "Pore Geometry of Ceramic Device: the Key Factor of Drug Release Kinetics" in Science of Sintering, 45, no. 1 (2013):107-116, https://doi.org/10.2298/SOS1301107C . .