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dc.creatorČolović, Božana M.
dc.creatorPašalić, Snežana
dc.creatorJokanović, Vukoman R.
dc.date.accessioned2018-03-01T22:50:16Z
dc.date.available2018-03-01T22:50:16Z
dc.date.issued2012
dc.identifier.issn0272-8842 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/5086
dc.description.abstractCalcium hydroxyapatite (CHA), as one of the most important ceramic materials in bone tissue engineering, was used as a delivery system for tigecycline, a potential antibiotic in treatment of osteomyelitis. Tigecycline, in a solid state, was mixed with CHA powder and the obtained mixture was compressed into tablets. The release of tigecycline from these tablets in a pH 7.4 phosphate-buffered saline solution was measured by a UV-vis spectrophotometer at 37 degrees C. The total dose of tigecycline was released for 5 to 30 days, depending on the applied pressure and drug concentration. A new drug release mechanism that determines the relationship between pore sizes and drug release rate is proposed. It explains and quantifies the drug release kinetics based on pore sizes and pore size distribution. (c) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.rightsrestrictedAccessen
dc.sourceCeramics Internationalen
dc.subjectPore geometryen
dc.subjectHydroxyapatiteen
dc.subjectMultilevel carrieren
dc.subjectDrug releaseen
dc.titleInfluence of hydroxyapatite pore geometry on tigecycline release kineticsen
dc.typearticleen
dcterms.abstractЈокановић Вукоман Р.; Чоловић Божана; Пашалић Снежана;
dc.citation.volume38
dc.citation.issue8
dc.citation.spage6181
dc.citation.epage6189
dc.identifier.wos000309645000014
dc.identifier.doi10.1016/j.ceramint.2012.04.069
dc.citation.rankM21
dc.identifier.scopus2-s2.0-84865749473


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