Forced exercise changes catecholamine synthesis in the spleen of adult rats
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Gavrilović, LjubicaStojiljković, Vesna
Kasapović, Jelena
Pejić, Snežana
Todorović, Ana
Pajović, Snežana B.
Dronjak, Slađana
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Treadmill training produces modulation of neuro-endocrine and immune functions. This study examined the effects of chronic forced running (CFR) on the plasma concentration of catecholamines and the expression of splenic catecholamine biosynthetic enzymes in rats by using real-time RT-PCR and Western blot analyses. We found that CFR increases the plasma catecholamine levels, decreases splenic tyrosine hydroxylase (TH), dopamine-p-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) mRNA levels and increases splenic PNMT protein levels. This shows that CFR is a very strong stressor which activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 20%, which both can modulate the immune function. (C) 2012 Elsevier B.V. All rights reserved.
Keywords:
Chronic forced running / Catecholamine / Spleen / Rats / qRT-PCRSource:
Journal of Neuroimmunology, 2012, 251, 1-2, 1-5Funding / projects:
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Acute coronary syndrome: investigation of vulnerability (plaque, blood and myocardium), optimal treatment and determination of the factors for the prognosis (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41022)
- Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-MESTD-Basic Research (BR or ON)-173044)
DOI: 10.1016/j.jneuroim.2012.06.002
ISSN: 0165-5728
PubMed: 22717206
WoS: 000309314700001
Scopus: 2-s2.0-84865620618
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VinčaTY - JOUR AU - Gavrilović, Ljubica AU - Stojiljković, Vesna AU - Kasapović, Jelena AU - Pejić, Snežana AU - Todorović, Ana AU - Pajović, Snežana B. AU - Dronjak, Slađana PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5057 AB - Treadmill training produces modulation of neuro-endocrine and immune functions. This study examined the effects of chronic forced running (CFR) on the plasma concentration of catecholamines and the expression of splenic catecholamine biosynthetic enzymes in rats by using real-time RT-PCR and Western blot analyses. We found that CFR increases the plasma catecholamine levels, decreases splenic tyrosine hydroxylase (TH), dopamine-p-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) mRNA levels and increases splenic PNMT protein levels. This shows that CFR is a very strong stressor which activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 20%, which both can modulate the immune function. (C) 2012 Elsevier B.V. All rights reserved. T2 - Journal of Neuroimmunology T1 - Forced exercise changes catecholamine synthesis in the spleen of adult rats VL - 251 IS - 1-2 SP - 1 EP - 5 DO - 10.1016/j.jneuroim.2012.06.002 ER -
@article{ author = "Gavrilović, Ljubica and Stojiljković, Vesna and Kasapović, Jelena and Pejić, Snežana and Todorović, Ana and Pajović, Snežana B. and Dronjak, Slađana", year = "2012", abstract = "Treadmill training produces modulation of neuro-endocrine and immune functions. This study examined the effects of chronic forced running (CFR) on the plasma concentration of catecholamines and the expression of splenic catecholamine biosynthetic enzymes in rats by using real-time RT-PCR and Western blot analyses. We found that CFR increases the plasma catecholamine levels, decreases splenic tyrosine hydroxylase (TH), dopamine-p-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) mRNA levels and increases splenic PNMT protein levels. This shows that CFR is a very strong stressor which activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 20%, which both can modulate the immune function. (C) 2012 Elsevier B.V. All rights reserved.", journal = "Journal of Neuroimmunology", title = "Forced exercise changes catecholamine synthesis in the spleen of adult rats", volume = "251", number = "1-2", pages = "1-5", doi = "10.1016/j.jneuroim.2012.06.002" }
Gavrilović, L., Stojiljković, V., Kasapović, J., Pejić, S., Todorović, A., Pajović, S. B.,& Dronjak, S.. (2012). Forced exercise changes catecholamine synthesis in the spleen of adult rats. in Journal of Neuroimmunology, 251(1-2), 1-5. https://doi.org/10.1016/j.jneuroim.2012.06.002
Gavrilović L, Stojiljković V, Kasapović J, Pejić S, Todorović A, Pajović SB, Dronjak S. Forced exercise changes catecholamine synthesis in the spleen of adult rats. in Journal of Neuroimmunology. 2012;251(1-2):1-5. doi:10.1016/j.jneuroim.2012.06.002 .
Gavrilović, Ljubica, Stojiljković, Vesna, Kasapović, Jelena, Pejić, Snežana, Todorović, Ana, Pajović, Snežana B., Dronjak, Slađana, "Forced exercise changes catecholamine synthesis in the spleen of adult rats" in Journal of Neuroimmunology, 251, no. 1-2 (2012):1-5, https://doi.org/10.1016/j.jneuroim.2012.06.002 . .