Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors
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Pejić, SnežanaStojiljković, Vesna
Todorović, Ana
Gavrilović, Ljubica
Popović, Nataša M.
Pavlović, Ivan
Pajović, Snežana B.
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Cancer of the reproductive tract is an important cause of morbidity and mortality among women worldwide. In this study we evaluated the influence of diagnostic categories, age and reproductive factors on antioxidant enzymes and lipid hydroperoxides in the blood of gynaecological patients diagnosed with endometrial polyp, myoma, hyperplasia simplex, hyperplasia complex and endometrial adenocarcinoma. Multivariate regression analysis was used to assess the association of diagnosis, age, parity, abortions and abnormal uterine bleeding with the examined parameters. Diagnosis provided the best predictive model for superoxide dismutase, catalase and glutathione peroxidase activities, and also for the lipid hydroperoxide level. Abortions fitted the best predictive model for superoxide dismutase activity. A significant correlation was also found between the predictor variables themselves. This study showed that reproductive and other factors may be associated, at least partially, with antioxid...ant capacity and ability to defend against the oxidative damage in gynaecological patients with various diagnoses.
Keywords:
antioxidant enzymes / reproductive factors / gynaecological patientsSource:
Folia Biologica, 2015, 61, 1, 26-32Funding / projects:
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-41027)
- Acute coronary syndrome: investigation of vulnerability (plaque, blood and myocardium), optimal treatment and determination of the factors for the prognosis (RS-41022)
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VinčaTY - JOUR AU - Pejić, Snežana AU - Stojiljković, Vesna AU - Todorović, Ana AU - Gavrilović, Ljubica AU - Popović, Nataša M. AU - Pavlović, Ivan AU - Pajović, Snežana B. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/498 AB - Cancer of the reproductive tract is an important cause of morbidity and mortality among women worldwide. In this study we evaluated the influence of diagnostic categories, age and reproductive factors on antioxidant enzymes and lipid hydroperoxides in the blood of gynaecological patients diagnosed with endometrial polyp, myoma, hyperplasia simplex, hyperplasia complex and endometrial adenocarcinoma. Multivariate regression analysis was used to assess the association of diagnosis, age, parity, abortions and abnormal uterine bleeding with the examined parameters. Diagnosis provided the best predictive model for superoxide dismutase, catalase and glutathione peroxidase activities, and also for the lipid hydroperoxide level. Abortions fitted the best predictive model for superoxide dismutase activity. A significant correlation was also found between the predictor variables themselves. This study showed that reproductive and other factors may be associated, at least partially, with antioxidant capacity and ability to defend against the oxidative damage in gynaecological patients with various diagnoses. T2 - Folia Biologica T1 - Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors VL - 61 IS - 1 SP - 26 EP - 32 UR - https://hdl.handle.net/21.15107/rcub_vinar_498 ER -
@article{ author = "Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Gavrilović, Ljubica and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.", year = "2015", abstract = "Cancer of the reproductive tract is an important cause of morbidity and mortality among women worldwide. In this study we evaluated the influence of diagnostic categories, age and reproductive factors on antioxidant enzymes and lipid hydroperoxides in the blood of gynaecological patients diagnosed with endometrial polyp, myoma, hyperplasia simplex, hyperplasia complex and endometrial adenocarcinoma. Multivariate regression analysis was used to assess the association of diagnosis, age, parity, abortions and abnormal uterine bleeding with the examined parameters. Diagnosis provided the best predictive model for superoxide dismutase, catalase and glutathione peroxidase activities, and also for the lipid hydroperoxide level. Abortions fitted the best predictive model for superoxide dismutase activity. A significant correlation was also found between the predictor variables themselves. This study showed that reproductive and other factors may be associated, at least partially, with antioxidant capacity and ability to defend against the oxidative damage in gynaecological patients with various diagnoses.", journal = "Folia Biologica", title = "Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors", volume = "61", number = "1", pages = "26-32", url = "https://hdl.handle.net/21.15107/rcub_vinar_498" }
Pejić, S., Stojiljković, V., Todorović, A., Gavrilović, L., Popović, N. M., Pavlović, I.,& Pajović, S. B.. (2015). Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors. in Folia Biologica, 61(1), 26-32. https://hdl.handle.net/21.15107/rcub_vinar_498
Pejić S, Stojiljković V, Todorović A, Gavrilović L, Popović NM, Pavlović I, Pajović SB. Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors. in Folia Biologica. 2015;61(1):26-32. https://hdl.handle.net/21.15107/rcub_vinar_498 .
Pejić, Snežana, Stojiljković, Vesna, Todorović, Ana, Gavrilović, Ljubica, Popović, Nataša M., Pavlović, Ivan, Pajović, Snežana B., "Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors" in Folia Biologica, 61, no. 1 (2015):26-32, https://hdl.handle.net/21.15107/rcub_vinar_498 .