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Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes

dc.creatorMrđanović, Jasminka Ž.
dc.creatorSolajic, Slavica V.
dc.creatorBogdanović, Višnja V.
dc.creatorĐorđević, Aleksandar N.
dc.creatorBogdanović, Gordana M.
dc.creatorInjac, Rade D.
dc.creatorRakočević, Zlatko Lj.
dc.date.accessioned2018-03-01T22:37:18Z
dc.date.available2018-03-01T22:37:18Z
dc.date.issued2012
dc.identifier.issn1842-3582
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/4935
dc.description.abstractFullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45005/RS//
dc.relationRepublic of Serbia, Republic of Slovenia [69-00-00012/2010-01/19]
dc.rightsrestrictedAccessen
dc.sourceDigest Journal of Nanomaterials and Biostructuresen
dc.subjectFullerenolen
dc.subjectnano particlesen
dc.subjectchromosomal aberrationen
dc.subjectmicronucleien
dc.subjectgenotoxicityen
dc.subjectantigenotoxicityen
dc.titleEffects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytesen
dc.typearticleen
dcterms.abstractМрдановиц, Јасминка З.; Богдановиц, Висња В.; Дјордјевиц, Aлександар Н.; Богдановиц, Гордана М.; Ињац, Раде Д.; Солајиц, Славица В.; Ракочевић Златко Љ.;
dc.citation.volume7
dc.citation.issue2
dc.citation.spage673
dc.citation.epage686
dc.identifier.wos000306063200031
dc.citation.rankM23
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_vinar_4935


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