Maternal Deprivation of Rat Pups Reduces Body Weight and Alters Behavior in Adulthood in a Gender-Specific Manner
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The early postnatal environment is critical for its capacity to influence adult behavior, and is associated with traits of altered physiological and neurobiological function and long-term predisposition to depression. Here we describe the delayed effects of maternal deprivation (MD) in male and female Wistar pups on their physical development and behavior in adulthood in tasks designed to explore depressive-like (forced swimming test, FST), and anxiety-like behaviors (elevated plus maze, EPM). We observed that MD led to reduced body weight in adulthood, anxiety-like traits in the EPM test and increased activity in the phases of the FST. Particularly, a consistent sexual dimorphism was observed in the responses to MD. A lower increase in body weight during maturation of MD rats was more pronounced in males than in females. MD anxiogenic effects were more pronounced in females, while in FST only MD males showed a marked increase in swimming activity followed by decreased immobility.
Ključne reči:
Maternal deprivation / behavior / forced swimming test / elevated plus mazeIzvor:
Archives of Biological Sciences, 2015, 67, 1, 131-138Finansiranje / projekti:
- Definisanje klastera molekulskih biomarkera za poboljšanu dijagnostiku i terapiju poremećaja raspoloženja (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41029)
DOI: 10.2298/ABS141002015D
ISSN: 0354-4664; 1821-4339
WoS: 000352003500014
Scopus: 2-s2.0-84937399971
Institucija/grupa
VinčaTY - JOUR AU - Đorđević, Jelena D. AU - Mitić, Miloš AU - Lukić, Iva AU - Adžić, Miroslav PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/477 AB - The early postnatal environment is critical for its capacity to influence adult behavior, and is associated with traits of altered physiological and neurobiological function and long-term predisposition to depression. Here we describe the delayed effects of maternal deprivation (MD) in male and female Wistar pups on their physical development and behavior in adulthood in tasks designed to explore depressive-like (forced swimming test, FST), and anxiety-like behaviors (elevated plus maze, EPM). We observed that MD led to reduced body weight in adulthood, anxiety-like traits in the EPM test and increased activity in the phases of the FST. Particularly, a consistent sexual dimorphism was observed in the responses to MD. A lower increase in body weight during maturation of MD rats was more pronounced in males than in females. MD anxiogenic effects were more pronounced in females, while in FST only MD males showed a marked increase in swimming activity followed by decreased immobility. T2 - Archives of Biological Sciences T1 - Maternal Deprivation of Rat Pups Reduces Body Weight and Alters Behavior in Adulthood in a Gender-Specific Manner VL - 67 IS - 1 SP - 131 EP - 138 DO - 10.2298/ABS141002015D ER -
@article{ author = "Đorđević, Jelena D. and Mitić, Miloš and Lukić, Iva and Adžić, Miroslav", year = "2015", abstract = "The early postnatal environment is critical for its capacity to influence adult behavior, and is associated with traits of altered physiological and neurobiological function and long-term predisposition to depression. Here we describe the delayed effects of maternal deprivation (MD) in male and female Wistar pups on their physical development and behavior in adulthood in tasks designed to explore depressive-like (forced swimming test, FST), and anxiety-like behaviors (elevated plus maze, EPM). We observed that MD led to reduced body weight in adulthood, anxiety-like traits in the EPM test and increased activity in the phases of the FST. Particularly, a consistent sexual dimorphism was observed in the responses to MD. A lower increase in body weight during maturation of MD rats was more pronounced in males than in females. MD anxiogenic effects were more pronounced in females, while in FST only MD males showed a marked increase in swimming activity followed by decreased immobility.", journal = "Archives of Biological Sciences", title = "Maternal Deprivation of Rat Pups Reduces Body Weight and Alters Behavior in Adulthood in a Gender-Specific Manner", volume = "67", number = "1", pages = "131-138", doi = "10.2298/ABS141002015D" }
Đorđević, J. D., Mitić, M., Lukić, I.,& Adžić, M.. (2015). Maternal Deprivation of Rat Pups Reduces Body Weight and Alters Behavior in Adulthood in a Gender-Specific Manner. in Archives of Biological Sciences, 67(1), 131-138. https://doi.org/10.2298/ABS141002015D
Đorđević JD, Mitić M, Lukić I, Adžić M. Maternal Deprivation of Rat Pups Reduces Body Weight and Alters Behavior in Adulthood in a Gender-Specific Manner. in Archives of Biological Sciences. 2015;67(1):131-138. doi:10.2298/ABS141002015D .
Đorđević, Jelena D., Mitić, Miloš, Lukić, Iva, Adžić, Miroslav, "Maternal Deprivation of Rat Pups Reduces Body Weight and Alters Behavior in Adulthood in a Gender-Specific Manner" in Archives of Biological Sciences, 67, no. 1 (2015):131-138, https://doi.org/10.2298/ABS141002015D . .