Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients
2012
Аутори
Stojiljković, VesnaPejić, Snežana
Kasapović, Jelena
Gavrilović, Ljubica
Stojiljković, Stanimir
Nikolić, Dragan
Pajović, Snežana B.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
The celiac disease is an autoimmune gastrointestinal disorder caused by gluten from wheat, rye or barley. In genetically predisposed persons, gluten induces the immune-mediated inflammation of small intestinal mucosa. Histological lesions include intraepithelial lymphocytosis, crypt hypertrophy and villous atrophy, resulting in malabsorption of micro- and macronutrients. The only treatment for celiac patients is a permanent gluten-free diet (GFD). Reactive oxygen species (ROS) and oxidative stress are strongly associated with the celiac disease. Glutathione (GSH) is a main detoxifier of endogenous and exogenous ROS in the intestine. In order to explain the role of glutathione redox cycle in celiac patients, we examined the activities of GSH-related antioxidant (AO) enzymes glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the concentration of GSH in small intestinal biopsies and peripheral blood of children affected by the celiac disease. The concentration of lipi...d hydroperoxides (LOOH) as markers of oxidative damage was measured in the same samples. The results clearly demonstrate a significant malfunction of GSH redox cycle with a concomitant decrease in the capacity to regenerate GSH and detoxify LOOH in celiac patients, even after several years of GFD. The oral administration of GSH and a diet rich in natural antioxidants, as well as appropriate dietary supplements, could be of great benefit to the patients.
Кључне речи:
antioxidant enzymes / celiac disease / glutathione / lipid peroxidationИзвор:
Anais de Academia Brasileira de Ciencias, 2012, 84, 1, 175-184Финансирање / пројекти:
- Ћелијске и молекулске основе малигних и кардиоваскуларних обољења-клиничке импликације (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Молекуларно физиолошки биомониторинг аеробних организама заснован на одређивању биохемијских биомаркера оксидационог стреса (RS-MESTD-Basic Research (BR or ON)-173041)
DOI: 10.1590/S0001-37652012000100018
ISSN: 0001-3765
PubMed: 22441607
WoS: 000301952900018
Scopus: 2-s2.0-84859031624
Колекције
Институција/група
VinčaTY - JOUR AU - Stojiljković, Vesna AU - Pejić, Snežana AU - Kasapović, Jelena AU - Gavrilović, Ljubica AU - Stojiljković, Stanimir AU - Nikolić, Dragan AU - Pajović, Snežana B. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4758 AB - The celiac disease is an autoimmune gastrointestinal disorder caused by gluten from wheat, rye or barley. In genetically predisposed persons, gluten induces the immune-mediated inflammation of small intestinal mucosa. Histological lesions include intraepithelial lymphocytosis, crypt hypertrophy and villous atrophy, resulting in malabsorption of micro- and macronutrients. The only treatment for celiac patients is a permanent gluten-free diet (GFD). Reactive oxygen species (ROS) and oxidative stress are strongly associated with the celiac disease. Glutathione (GSH) is a main detoxifier of endogenous and exogenous ROS in the intestine. In order to explain the role of glutathione redox cycle in celiac patients, we examined the activities of GSH-related antioxidant (AO) enzymes glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the concentration of GSH in small intestinal biopsies and peripheral blood of children affected by the celiac disease. The concentration of lipid hydroperoxides (LOOH) as markers of oxidative damage was measured in the same samples. The results clearly demonstrate a significant malfunction of GSH redox cycle with a concomitant decrease in the capacity to regenerate GSH and detoxify LOOH in celiac patients, even after several years of GFD. The oral administration of GSH and a diet rich in natural antioxidants, as well as appropriate dietary supplements, could be of great benefit to the patients. T2 - Anais de Academia Brasileira de Ciencias T1 - Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients VL - 84 IS - 1 SP - 175 EP - 184 DO - 10.1590/S0001-37652012000100018 ER -
@article{ author = "Stojiljković, Vesna and Pejić, Snežana and Kasapović, Jelena and Gavrilović, Ljubica and Stojiljković, Stanimir and Nikolić, Dragan and Pajović, Snežana B.", year = "2012", abstract = "The celiac disease is an autoimmune gastrointestinal disorder caused by gluten from wheat, rye or barley. In genetically predisposed persons, gluten induces the immune-mediated inflammation of small intestinal mucosa. Histological lesions include intraepithelial lymphocytosis, crypt hypertrophy and villous atrophy, resulting in malabsorption of micro- and macronutrients. The only treatment for celiac patients is a permanent gluten-free diet (GFD). Reactive oxygen species (ROS) and oxidative stress are strongly associated with the celiac disease. Glutathione (GSH) is a main detoxifier of endogenous and exogenous ROS in the intestine. In order to explain the role of glutathione redox cycle in celiac patients, we examined the activities of GSH-related antioxidant (AO) enzymes glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the concentration of GSH in small intestinal biopsies and peripheral blood of children affected by the celiac disease. The concentration of lipid hydroperoxides (LOOH) as markers of oxidative damage was measured in the same samples. The results clearly demonstrate a significant malfunction of GSH redox cycle with a concomitant decrease in the capacity to regenerate GSH and detoxify LOOH in celiac patients, even after several years of GFD. The oral administration of GSH and a diet rich in natural antioxidants, as well as appropriate dietary supplements, could be of great benefit to the patients.", journal = "Anais de Academia Brasileira de Ciencias", title = "Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients", volume = "84", number = "1", pages = "175-184", doi = "10.1590/S0001-37652012000100018" }
Stojiljković, V., Pejić, S., Kasapović, J., Gavrilović, L., Stojiljković, S., Nikolić, D.,& Pajović, S. B.. (2012). Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients. in Anais de Academia Brasileira de Ciencias, 84(1), 175-184. https://doi.org/10.1590/S0001-37652012000100018
Stojiljković V, Pejić S, Kasapović J, Gavrilović L, Stojiljković S, Nikolić D, Pajović SB. Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients. in Anais de Academia Brasileira de Ciencias. 2012;84(1):175-184. doi:10.1590/S0001-37652012000100018 .
Stojiljković, Vesna, Pejić, Snežana, Kasapović, Jelena, Gavrilović, Ljubica, Stojiljković, Stanimir, Nikolić, Dragan, Pajović, Snežana B., "Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients" in Anais de Academia Brasileira de Ciencias, 84, no. 1 (2012):175-184, https://doi.org/10.1590/S0001-37652012000100018 . .