Приказ основних података о документу
The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy
dc.creator | Kolaković, Ana | |
dc.creator | Živković, Maja | |
dc.creator | Radak, Đorđe J. | |
dc.creator | Đurić, Tamara | |
dc.creator | Končar, Igor | |
dc.creator | Davidović, Lazar | |
dc.creator | Dinčić, Dragan | |
dc.creator | Alavantić, Dragan | |
dc.creator | Stanković, Aleksandra | |
dc.date.accessioned | 2018-03-01T22:18:51Z | |
dc.date.available | 2018-03-01T22:18:51Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1470-3203 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/4719 | |
dc.description.abstract | Introduction: The ACE I/D polymorphism was mostly investigated in association with intima-media thickness, rarely with severe atherosclerotic phenotype. Materials and methods: We investigated the association of I/D polymorphism with severe carotid atherosclerosis (CA) (stenosis GT 70%) in asymptomatic and symptomatic patients undergoing carotid endarterectomy. The 504 patients subjected to endarterectomy and 492 healthy controls from a population in Serbia were investigated as a case-control study. Results: The univariate logistic regression analysis revealed ACE DD as a significant risk factor for severe CA (odds ratio [OR] = 1.3, 95% confidence interval [CI] 1.0-1.7, p = 0.04). After adjustment for the common risk factors (age, hypertension, smoking, and HDL) ACE was no longer significant. However, we found a significant independent influence of DD genotype on plaque presence in a normotensive subgroup of patients (OR 1.8, CI 1.2-3.0, p = 0.01, corrected for multiple testing). In symptomatic patients D allele carriers were significantly more frequent compared with asymptomatic patients (OR 1.6 CI 1.0-2.6, p = 0.05). Conclusions: Our data suggests that ACE I/D is not an independent risk factor for severe CA. On the other hand, a significant independent genetic influence of ACE I/D appeared in normotensive and symptomatic patients with severe CA. This should be considered in further research toward resolving the complex genetic background of severe CA phenotype. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41028/RS// | |
dc.rights | openAccess | en |
dc.source | Journal of the Renin-Angiotensin-Aldosterone System | en |
dc.subject | ACE I | en |
dc.subject | D | en |
dc.subject | carotid plaque | en |
dc.subject | endarterectomy | en |
dc.subject | gene | en |
dc.subject | polymorphism | en |
dc.title | The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy | en |
dc.type | article | en |
dcterms.abstract | Живковић Маја; Станковић Aлександра; Aлавантић Драган; Ђурић Тамара; Радак, Дјордје; Колаковић Aна; Концар, Игор; Давидовиц, Лазар; Динциц, Драган; | |
dc.citation.volume | 13 | |
dc.citation.issue | 1 | |
dc.citation.spage | 141 | |
dc.citation.epage | 147 | |
dc.identifier.wos | 000300993400019 | |
dc.identifier.doi | 10.1177/1470320311423271 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 21984781 | |
dc.identifier.scopus | 2-s2.0-84859969050 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/12973/4715.pdf |