Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice
Нема приказа
Аутори
Petrusic, VladimirTodorović, Nevena
Zivkovic, Irena
Dimitrijevic, Rajna
Muhandes, Lina
Rajnpreht, Irena
Dimitrijevic, Ljiljana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Recent data concerning antiphospholipid syndrome (APS) induction have shown that beta(2)-glycoprotein I (beta(2)GPI) binds lipopolysaccharide (LPS), which results in conformational changes, exposition of a cryptic epitope and possible pathological anti-beta(2)GPI antibody production. In order to investigate the effects of LPS on the induction of APS-related pathology, we performed hyperimmunization of BALB/c and C57BL/6 mice with LPS, alone or in combination with tetanus toxoid (TTd), a protein structurally similar to beta(2)GPI. We report that, although high affinity pathological anti-beta(2)GPI antibodies were produced in all groups of animals, the reproductive pathology was recorded only in mice that received both LPS and TTd, implying on the important roles of both infections and molecular mimicry in APS pathogenesis. Moreover, APS-related reproductive pathology was more pronounced in BALB/c (lowered fertility and fecundity) than C57BL/6 mice (lowered fecundity), which correlated w...ell with the disruption in natural antibody network observed in BALB/c mouse strain.
Кључне речи:
beta(2)-glycoprotein I / antiphospholipid syndrome / fertility / molecular mimicry / natural antibodiesИзвор:
Autoimmunity, 2015, 48, 2, 87-99Финансирање / пројекти:
- Алергени, антитела, ензими и мали физиолошки значајни молекули: дизајн, структура, функција и значај (RS-172049)
DOI: 10.3109/08916934.2014.961061
ISSN: 0891-6934; 1607-842X
PubMed: 25430703
WoS: 000351610300004
Scopus: 2-s2.0-84924975517
Колекције
Институција/група
VinčaTY - JOUR AU - Petrusic, Vladimir AU - Todorović, Nevena AU - Zivkovic, Irena AU - Dimitrijevic, Rajna AU - Muhandes, Lina AU - Rajnpreht, Irena AU - Dimitrijevic, Ljiljana PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/465 AB - Recent data concerning antiphospholipid syndrome (APS) induction have shown that beta(2)-glycoprotein I (beta(2)GPI) binds lipopolysaccharide (LPS), which results in conformational changes, exposition of a cryptic epitope and possible pathological anti-beta(2)GPI antibody production. In order to investigate the effects of LPS on the induction of APS-related pathology, we performed hyperimmunization of BALB/c and C57BL/6 mice with LPS, alone or in combination with tetanus toxoid (TTd), a protein structurally similar to beta(2)GPI. We report that, although high affinity pathological anti-beta(2)GPI antibodies were produced in all groups of animals, the reproductive pathology was recorded only in mice that received both LPS and TTd, implying on the important roles of both infections and molecular mimicry in APS pathogenesis. Moreover, APS-related reproductive pathology was more pronounced in BALB/c (lowered fertility and fecundity) than C57BL/6 mice (lowered fecundity), which correlated well with the disruption in natural antibody network observed in BALB/c mouse strain. T2 - Autoimmunity T1 - Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice VL - 48 IS - 2 SP - 87 EP - 99 DO - 10.3109/08916934.2014.961061 ER -
@article{ author = "Petrusic, Vladimir and Todorović, Nevena and Zivkovic, Irena and Dimitrijevic, Rajna and Muhandes, Lina and Rajnpreht, Irena and Dimitrijevic, Ljiljana", year = "2015", abstract = "Recent data concerning antiphospholipid syndrome (APS) induction have shown that beta(2)-glycoprotein I (beta(2)GPI) binds lipopolysaccharide (LPS), which results in conformational changes, exposition of a cryptic epitope and possible pathological anti-beta(2)GPI antibody production. In order to investigate the effects of LPS on the induction of APS-related pathology, we performed hyperimmunization of BALB/c and C57BL/6 mice with LPS, alone or in combination with tetanus toxoid (TTd), a protein structurally similar to beta(2)GPI. We report that, although high affinity pathological anti-beta(2)GPI antibodies were produced in all groups of animals, the reproductive pathology was recorded only in mice that received both LPS and TTd, implying on the important roles of both infections and molecular mimicry in APS pathogenesis. Moreover, APS-related reproductive pathology was more pronounced in BALB/c (lowered fertility and fecundity) than C57BL/6 mice (lowered fecundity), which correlated well with the disruption in natural antibody network observed in BALB/c mouse strain.", journal = "Autoimmunity", title = "Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice", volume = "48", number = "2", pages = "87-99", doi = "10.3109/08916934.2014.961061" }
Petrusic, V., Todorović, N., Zivkovic, I., Dimitrijevic, R., Muhandes, L., Rajnpreht, I.,& Dimitrijevic, L.. (2015). Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice. in Autoimmunity, 48(2), 87-99. https://doi.org/10.3109/08916934.2014.961061
Petrusic V, Todorović N, Zivkovic I, Dimitrijevic R, Muhandes L, Rajnpreht I, Dimitrijevic L. Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice. in Autoimmunity. 2015;48(2):87-99. doi:10.3109/08916934.2014.961061 .
Petrusic, Vladimir, Todorović, Nevena, Zivkovic, Irena, Dimitrijevic, Rajna, Muhandes, Lina, Rajnpreht, Irena, Dimitrijevic, Ljiljana, "Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice" in Autoimmunity, 48, no. 2 (2015):87-99, https://doi.org/10.3109/08916934.2014.961061 . .