Distinct and combined effects of acute immobilization and chronic isolation stress on MAO activity and antioxidative protection in the heart of normotensive and spontaneously hypertensive rats
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Аутори
Đorđević, Jelena D.Jasnic, N.
Vujovic, P.
Lakic, I.
Djurasevic, S.
Gavrilović, Ljubica
Cvijic, G.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
The heart is an organ especially sensitive to the sympathetic overstimulation and therefore to the influence of stressors and hypertension. The aim of the present study was to investigate the effect of two distinct types of stressors, acute immobilization (2 h) and chronic isolation stress (21 days), as well as their combined effect on the activity of monoamine oxidase (MAO), superoxide dismutase, catalase (CAT) and the ascorbic acid (AA) content in the heart of normotensive and spontaneously hypertensive rats (SHR). The results obtained show that in basal conditions heart MAO and CAT activity (p LT 0.05), as well as AA concentration (p LT 0.01) were higher in SHR than in normotensive ones. The acute immobilization significantly decreased heart MAO activity in both examined strains (p LT 0.01). On the other hand, chronic isolation, separately or in combination with immobilization, did not affect this enzyme, in the heart of either hypertensive or normotensive rats, which was associated... with the reduced antioxidative protection (p LT 0.01, p LT 0.05).
Кључне речи:
antioxidative protection / stress / heart / MAO / SHRИзвор:
Journal of Animal Physiology and Animal Nutrition, 2012, 96, 1, 58-65Финансирање / пројекти:
- Ефекат метаболичких и неметаболичких стресора на експресију и деловање неуроендокриних регулатора енергетске хомеостазе (RS-MESTD-Basic Research (BR or ON)-173023)
DOI: 10.1111/j.1439-0396.2010.01122.x
ISSN: 0931-2439
PubMed: 21244524
WoS: 000298956500008
Scopus: 2-s2.0-84855731729
Колекције
Институција/група
VinčaTY - JOUR AU - Đorđević, Jelena D. AU - Jasnic, N. AU - Vujovic, P. AU - Lakic, I. AU - Djurasevic, S. AU - Gavrilović, Ljubica AU - Cvijic, G. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4647 AB - The heart is an organ especially sensitive to the sympathetic overstimulation and therefore to the influence of stressors and hypertension. The aim of the present study was to investigate the effect of two distinct types of stressors, acute immobilization (2 h) and chronic isolation stress (21 days), as well as their combined effect on the activity of monoamine oxidase (MAO), superoxide dismutase, catalase (CAT) and the ascorbic acid (AA) content in the heart of normotensive and spontaneously hypertensive rats (SHR). The results obtained show that in basal conditions heart MAO and CAT activity (p LT 0.05), as well as AA concentration (p LT 0.01) were higher in SHR than in normotensive ones. The acute immobilization significantly decreased heart MAO activity in both examined strains (p LT 0.01). On the other hand, chronic isolation, separately or in combination with immobilization, did not affect this enzyme, in the heart of either hypertensive or normotensive rats, which was associated with the reduced antioxidative protection (p LT 0.01, p LT 0.05). T2 - Journal of Animal Physiology and Animal Nutrition T1 - Distinct and combined effects of acute immobilization and chronic isolation stress on MAO activity and antioxidative protection in the heart of normotensive and spontaneously hypertensive rats VL - 96 IS - 1 SP - 58 EP - 65 DO - 10.1111/j.1439-0396.2010.01122.x ER -
@article{ author = "Đorđević, Jelena D. and Jasnic, N. and Vujovic, P. and Lakic, I. and Djurasevic, S. and Gavrilović, Ljubica and Cvijic, G.", year = "2012", abstract = "The heart is an organ especially sensitive to the sympathetic overstimulation and therefore to the influence of stressors and hypertension. The aim of the present study was to investigate the effect of two distinct types of stressors, acute immobilization (2 h) and chronic isolation stress (21 days), as well as their combined effect on the activity of monoamine oxidase (MAO), superoxide dismutase, catalase (CAT) and the ascorbic acid (AA) content in the heart of normotensive and spontaneously hypertensive rats (SHR). The results obtained show that in basal conditions heart MAO and CAT activity (p LT 0.05), as well as AA concentration (p LT 0.01) were higher in SHR than in normotensive ones. The acute immobilization significantly decreased heart MAO activity in both examined strains (p LT 0.01). On the other hand, chronic isolation, separately or in combination with immobilization, did not affect this enzyme, in the heart of either hypertensive or normotensive rats, which was associated with the reduced antioxidative protection (p LT 0.01, p LT 0.05).", journal = "Journal of Animal Physiology and Animal Nutrition", title = "Distinct and combined effects of acute immobilization and chronic isolation stress on MAO activity and antioxidative protection in the heart of normotensive and spontaneously hypertensive rats", volume = "96", number = "1", pages = "58-65", doi = "10.1111/j.1439-0396.2010.01122.x" }
Đorđević, J. D., Jasnic, N., Vujovic, P., Lakic, I., Djurasevic, S., Gavrilović, L.,& Cvijic, G.. (2012). Distinct and combined effects of acute immobilization and chronic isolation stress on MAO activity and antioxidative protection in the heart of normotensive and spontaneously hypertensive rats. in Journal of Animal Physiology and Animal Nutrition, 96(1), 58-65. https://doi.org/10.1111/j.1439-0396.2010.01122.x
Đorđević JD, Jasnic N, Vujovic P, Lakic I, Djurasevic S, Gavrilović L, Cvijic G. Distinct and combined effects of acute immobilization and chronic isolation stress on MAO activity and antioxidative protection in the heart of normotensive and spontaneously hypertensive rats. in Journal of Animal Physiology and Animal Nutrition. 2012;96(1):58-65. doi:10.1111/j.1439-0396.2010.01122.x .
Đorđević, Jelena D., Jasnic, N., Vujovic, P., Lakic, I., Djurasevic, S., Gavrilović, Ljubica, Cvijic, G., "Distinct and combined effects of acute immobilization and chronic isolation stress on MAO activity and antioxidative protection in the heart of normotensive and spontaneously hypertensive rats" in Journal of Animal Physiology and Animal Nutrition, 96, no. 1 (2012):58-65, https://doi.org/10.1111/j.1439-0396.2010.01122.x . .