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dc.creatorSpasojević, Nataša
dc.creatorGavrilović, Ljubica
dc.creatorDronjak, Slađana
dc.date.accessioned2018-03-01T22:09:30Z
dc.date.available2018-03-01T22:09:30Z
dc.date.issued2011
dc.identifier.issn0231-424X (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/4610
dc.description.abstractChronic stress is a risk factor for the development of numerous psychopathological conditions in humans including depression. Changes in gene expression of tyrosine-hydroxylase (TH), dopamine-beta-hydroxylase (DBH) phenylethanolamine N-methyltransferase (PNMT), beta(1)-, beta(2)-and beta(3)-adrenoceptors in right and left rat atria upon chronic unpredictable mild stress (CMS) were investigated. CMS decreased TH and DBH gene expression levels both in right and left atria and increased PNMT mRNA in left atria. No changes in mRNA levels of beta(1)-and beta(2) adrenoceptors were recorded, whereas beta(3)-adrenoreceptor mRNA level was significantly elevated in right atria of CMS rats. At the same time, CMS produced a significant increase of beta(1)-and beta(2)-adrenoreceptor mRNA levels in left atria, but did not affect beta(3)-adrenoceptor mRNA level. The results presented here suggest that stress-induced depression expressed differential effects on catecholamine biosynthetic enzymes and beta-adrenoceptors at molecular level in right and left atria of adult rat males. Elevated gene expression of PNMT in left atria of rats exposed to CMS can lead to altered physiological esponse and may play a role in the pathophysiology of cardiovascular function.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.rightsrestrictedAccessen
dc.sourceActa Physiologica Hungaricaen
dc.subjectatriaen
dc.subjectcatecholamine enzymesen
dc.subjectbeta-adrenoceptorsen
dc.subjectgene expressionen
dc.subjectstressen
dc.subjectgene expressionen
dc.subjectmRNAen
dc.subjectstress-induced depressionen
dc.titleRegulation of atrial catecholamine enzymes and adrenoceptor gene expression after chronic stressen
dc.typearticleen
dcterms.abstractГавриловић Љубица; Спасојевић Наташа; Дроњак Слађана;
dc.citation.volume98
dc.citation.issue4
dc.citation.spage433
dc.citation.epage441
dc.identifier.wos000298107500006
dc.identifier.doi10.1556/APhysiol.98.2011.4.6
dc.citation.rankM23
dc.identifier.pmid22173024
dc.identifier.scopus2-s2.0-84255201493


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