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dc.creatorVujačić, Ana V.
dc.creatorVodnik, Vesna
dc.creatorJoksić, Gordana
dc.creatorPetrović, Sandra
dc.creatorLeskovac, Andreja
dc.creatorNastasijević, Branislav J.
dc.creatorVasić, Vesna M.
dc.date.accessioned2018-03-01T22:09:09Z
dc.date.available2018-03-01T22:09:09Z
dc.date.issued2011
dc.identifier.issn1842-3582 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/4606
dc.description.abstractThe spherical gold nanoparticles (NPs) of different average size (15 nm and 47 nm) prepared by citrate reduction were used to examine their cytotoxic effects. UV-vis spectrophotometry, transmission electron microscopy (TEM), dynamic light scattering (DLS) and zeta potential measurements were used to characterize the gold NPs. We have investigated the concentration and size dependent cytotoxic effects of gold NPs, using two in vitro human cells model systems: proliferating lymphocytes and connective tissue fibroblasts. Treatment of lymphocyte cultures with Au NPs caused cytotoxic effects as revealed by significant enhancement of incidence of micronuclei but non significant increase of cell proliferation potential when compared to the control. In a fibroblast cell line, the same doses of gold NPs induced the slightly higher level of gamma-H2AX foci than in a control. The presented results clearly indicate that the enhancement of micronuclei incidence and proliferation index depend not only on concentration but also the size of the nanoparticles.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172023/RS//
dc.rightsrestrictedAccessen
dc.sourceDigest Journal of Nanomaterials and Biostructuresen
dc.subjectgolden
dc.subjecthuman cellsen
dc.subjectnanoparticlesen
dc.subjectcytotoxicityen
dc.titleParticle Size and Concentration Dependent Cytotoxicity of Citrate Capped Gold Nanoparticlesen
dc.typearticleen
dcterms.abstractЈоксић Гордана; Петровић, Сандра; Васић Весна М; Лесковац Aндреја; Настасијевић Бранислав; Вујачић-Никезић Aна; Водник Весна;
dc.citation.volume6
dc.citation.issue3
dc.citation.spage1367
dc.citation.epage1376
dc.identifier.wos000297986100055
dc.citation.rankM22


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