Thrombin and vascular inflammation
Само за регистроване кориснике
2012
Аутори
Popović, MilanSmiljanić, Katarina
Dobutović, Branislava
Syrovets, Tatiana
Simmet, Thomas
Isenović, Esma R.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Vascular endothelium is a key regulator of homeostasis. In physiological conditions it mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. However, endothelial dysfunction caused by physical injury of the vascular wall, for example during balloon angioplasty, acute or chronic inflammation, such as in atherothrombosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites. At the same time, the dysfunction promotes thrombin generation, fibrin deposition, and coagulation. The serine protease thrombin plays a pivotal role in the coagulation cascade. However, thrombin is not only the key effector of coagulation cascade; it also plays a significant role in inflammatory diseases. It shows an array of effects on endothelial cells, vascular smooth muscle cells, monocytes, and platelets, all of which participate in the vascular pathophysiology such as atherothrombosis. Therefore, thrombin can be considered... as an important modulatory molecule of vascular homeostasis. This review summarizes the existing evidence on the role of thrombin in vascular inflammation.
Кључне речи:
Thrombin / Endothelium / Vascular inflammation / AtherosclerosisИзвор:
Molecular and Cellular Biochemistry, 2012, 359, 1-2, 301-313Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-173033)
- Генетска основа хуманих васкуларних и инфламаторних болести (RS-175085)
- Deutsche Forschungsgemeinschaft [Si 285/7-1]
DOI: 10.1007/s11010-011-1024-x
ISSN: 0300-8177; 1573-4919
PubMed: 21858738
WoS: 000297174700031
Scopus: 2-s2.0-83555164932
Колекције
Институција/група
VinčaTY - JOUR AU - Popović, Milan AU - Smiljanić, Katarina AU - Dobutović, Branislava AU - Syrovets, Tatiana AU - Simmet, Thomas AU - Isenović, Esma R. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4578 AB - Vascular endothelium is a key regulator of homeostasis. In physiological conditions it mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. However, endothelial dysfunction caused by physical injury of the vascular wall, for example during balloon angioplasty, acute or chronic inflammation, such as in atherothrombosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites. At the same time, the dysfunction promotes thrombin generation, fibrin deposition, and coagulation. The serine protease thrombin plays a pivotal role in the coagulation cascade. However, thrombin is not only the key effector of coagulation cascade; it also plays a significant role in inflammatory diseases. It shows an array of effects on endothelial cells, vascular smooth muscle cells, monocytes, and platelets, all of which participate in the vascular pathophysiology such as atherothrombosis. Therefore, thrombin can be considered as an important modulatory molecule of vascular homeostasis. This review summarizes the existing evidence on the role of thrombin in vascular inflammation. T2 - Molecular and Cellular Biochemistry T1 - Thrombin and vascular inflammation VL - 359 IS - 1-2 SP - 301 EP - 313 DO - 10.1007/s11010-011-1024-x ER -
@article{ author = "Popović, Milan and Smiljanić, Katarina and Dobutović, Branislava and Syrovets, Tatiana and Simmet, Thomas and Isenović, Esma R.", year = "2012", abstract = "Vascular endothelium is a key regulator of homeostasis. In physiological conditions it mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. However, endothelial dysfunction caused by physical injury of the vascular wall, for example during balloon angioplasty, acute or chronic inflammation, such as in atherothrombosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites. At the same time, the dysfunction promotes thrombin generation, fibrin deposition, and coagulation. The serine protease thrombin plays a pivotal role in the coagulation cascade. However, thrombin is not only the key effector of coagulation cascade; it also plays a significant role in inflammatory diseases. It shows an array of effects on endothelial cells, vascular smooth muscle cells, monocytes, and platelets, all of which participate in the vascular pathophysiology such as atherothrombosis. Therefore, thrombin can be considered as an important modulatory molecule of vascular homeostasis. This review summarizes the existing evidence on the role of thrombin in vascular inflammation.", journal = "Molecular and Cellular Biochemistry", title = "Thrombin and vascular inflammation", volume = "359", number = "1-2", pages = "301-313", doi = "10.1007/s11010-011-1024-x" }
Popović, M., Smiljanić, K., Dobutović, B., Syrovets, T., Simmet, T.,& Isenović, E. R.. (2012). Thrombin and vascular inflammation. in Molecular and Cellular Biochemistry, 359(1-2), 301-313. https://doi.org/10.1007/s11010-011-1024-x
Popović M, Smiljanić K, Dobutović B, Syrovets T, Simmet T, Isenović ER. Thrombin and vascular inflammation. in Molecular and Cellular Biochemistry. 2012;359(1-2):301-313. doi:10.1007/s11010-011-1024-x .
Popović, Milan, Smiljanić, Katarina, Dobutović, Branislava, Syrovets, Tatiana, Simmet, Thomas, Isenović, Esma R., "Thrombin and vascular inflammation" in Molecular and Cellular Biochemistry, 359, no. 1-2 (2012):301-313, https://doi.org/10.1007/s11010-011-1024-x . .