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dc.creatorSpasojević, Nataša
dc.creatorGavrilović, Ljubica
dc.creatorDronjak, Slađana
dc.date.accessioned2018-03-01T22:03:23Z
dc.date.available2018-03-01T22:03:23Z
dc.date.issued2011
dc.identifier.issn0862-8408 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/4539
dc.description.abstractStress exposure activates the sympathoneural system, resulting in catecholamine release. Chronic stress is associated with development of numerous disorders, including cardiovascular diseases. Here we investigated the expression of mRNAs for catecholamine biosynthetic enzymes tyrosine-hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase, and for beta(1)- and beta(2)-adrenoceptors in the right and left ventricles of rats exposed to chronic unpredictable mild stress. The tyrosine-hydroxylase and dopamine-beta-hydroxylase mRNA levels were not affected by stress, whereas the phenylethanolamine N-methyltransferase mRNA levels significantly increased in both right and left ventricles. No changes in beta(1)-adrenoceptor mRNA levels in either right or left ventricles were observed. At the same time, stress produced a significant increase of beta(2)-adrenoceptor mRNA levels in left ventricles. These results suggest that elevated expression of phenylethanolamine N-methyltransferase in both ventricules and beta(2)-adrenoceptor genes in left ventricles could provide a molecular mechanism that leads to altered physiological response, which is important for the organism coping with stress.en
dc.relationMinistry for Science and Technological Development of the Republic of Serbia [143044B]
dc.rightsrestrictedAccessen
dc.sourcePhysiological Researchen
dc.subjectChronic stressen
dc.subjectVentriclesen
dc.subjectCatecholamine enzymesen
dc.subjectbeta-adrenoceptorsen
dc.subjectGene expressionen
dc.titleRegulation of Catecholamine-Synthesising Enzymes and beta-Adrenoceptors Gene Expression in Ventricles of Stressed Ratsen
dc.typearticleen
dcterms.abstractДроњак Слађана; Гавриловић Љубица; Спасојевић Наташа;
dc.citation.volume60
dc.citation.spageS171
dc.citation.epageS176
dc.identifier.wos000296334200019
dc.citation.otherSuppl: 1
dc.citation.rankM23
dc.identifier.pmid21777029


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