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dc.creatorSmiljanić, Katarina
dc.creatorDobutovic, B.
dc.creatorObradović, Milan M.
dc.creatorNikolić, Dragana
dc.creatorMarche, Pierre
dc.creatorIsenović, Esma R.
dc.date.accessioned2018-03-01T21:57:14Z
dc.date.available2018-03-01T21:57:14Z
dc.date.issued2011
dc.identifier.issn0929-8673
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/4468
dc.description.abstractCardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on involvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.relationCNRS, University Pierre and Marie Curie, Pavle Savic [337-00-359/2005-01/16], Republic of France, Ministry of Foreign Affairs
dc.rightsrestrictedAccessen
dc.sourceCurrent Medicinal Chemistryen
dc.subjectADAM 12en
dc.subjectAtherosclerosisen
dc.subjectThrombinen
dc.subjectProliferationen
dc.subjectVSMCen
dc.subjectMMPen
dc.subjectCardiovascular diseasesen
dc.subjectHypertensionen
dc.subjectHypertrophyen
dc.subjectVascular diseasesen
dc.titleInvolvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferationen
dc.typereviewen
dcterms.abstractСмиљанић Катарина; Марцхе, П.; Добутовиц, Б.; Обрадовић Милан; Николић Драгана; Исеновић Есма;
dc.citation.volume18
dc.citation.issue22
dc.citation.spage3382
dc.citation.epage3386
dc.identifier.wos000294405600013
dc.identifier.doi10.2174/092986711796504709
dc.citation.rankM21a
dc.identifier.pmid21728962
dc.identifier.scopus2-s2.0-79961088085


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